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Sulfamides direct radical-mediated chlorination of aliphatic C–H bonds

Given the prevalence of aliphatic amines in bioactive small molecules, amine derivatives are opportune as directing groups. Herein, sulfamides serve as amine surrogates to guide intermolecular chlorine-transfer at γ-C(sp(3)) centers. This unusual position-selectivity arises because accessed sulfamid...

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Detalles Bibliográficos
Autores principales:	Short, Melanie A., Shehata, Mina F., Sanders, Matthew A., Roizen, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132995/ https://www.ncbi.nlm.nih.gov/pubmed/34040715 http://dx.doi.org/10.1039/c9sc03428e

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