Cargando…

Sulfamides direct radical-mediated chlorination of aliphatic C–H bonds

Given the prevalence of aliphatic amines in bioactive small molecules, amine derivatives are opportune as directing groups. Herein, sulfamides serve as amine surrogates to guide intermolecular chlorine-transfer at γ-C(sp(3)) centers. This unusual position-selectivity arises because accessed sulfamid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Short, Melanie A., Shehata, Mina F., Sanders, Matthew A., Roizen, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132995/ https://www.ncbi.nlm.nih.gov/pubmed/34040715 http://dx.doi.org/10.1039/c9sc03428e

Ejemplares similares

Iridium-catalysed direct sulfamidation of quinazolinones
por: Feng, Yadong, et al.
Publicado: (2018)

The formyloxyl radical: electrophilicity, C–H bond activation and anti-Markovnikov selectivity in the oxidation of aliphatic alkenes
por: Somekh, Miriam, et al.
Publicado: (2020)

A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C–H bonds
por: Wang, Yaxin, et al.
Publicado: (2016)

Direct Arylation of Strong Aliphatic C–H Bonds
por: Perry, Ian B., et al.
Publicado: (2018)

Benzylsulfamide
por: Gelbrich, Thomas, et al.
Publicado: (2011)

Intramolecular 1,5-C(sp(3))–H radical amination via Co(ii)-based metalloradical catalysis for five-membered cyclic sulfamides
por: Lu, Hongjian, et al.
Publicado: (2016)

The Pd-catalysed asymmetric allylic alkylation reactions of sulfamidate imines
por: Pham, Quoc Hoang, et al.
Publicado: (2021)

Site-selective functionalization of remote aliphatic C–H bonds via C–H metallation
por: Zhang, Qi, et al.
Publicado: (2020)

Synthesis of New Fused Benzothiadiazepines and Macrocyclic Sulfamides Starting from N,N-Disubstituted Sulfamides and N(Boc)-Sulfamides
por: Dehamchia, Mohamed, et al.
Publicado: (2012)

Synthesis of unsymmetrical sulfamides and polysulfamides via SuFEx click chemistry
por: Kulow, Ryan W., et al.
Publicado: (2020)

Chemo- and regioselective oxygenation of C(sp(3))–H bonds in aliphatic alcohols using a covalently bound directing activator and atmospheric oxygen
por: Ozawa, Jun, et al.
Publicado: (2016)

Reagent-dictated site selectivity in intermolecular aliphatic C–H functionalizations using nitrogen-centered radicals
por: Carestia, Anthony M., et al.
Publicado: (2018)

Nickel-Catalyzed Asymmetric Hydrogenation of Cyclic Sulfamidate Imines: Efficient Synthesis of Chiral Cyclic Sulfamidates
por: Liu, Yuanhua, et al.
Publicado: (2019)

Diverse secondary C(sp(3))–H bond functionalization via site-selective trifluoroacetoxylation of aliphatic amines
por: Tang, Yongzhen, et al.
Publicado: (2018)

Cobalt-catalysed C–H carbonylative cyclisation of aliphatic amides
por: Williamson, Patrick, et al.
Publicado: (2017)

Trifluoromethanesulfonamide vs. Non-Fluorinated Sulfonamides in Oxidative Sulfamidation of the C=C Bond: An In Silico Study
por: Kuzmin, Anton V., et al.
Publicado: (2020)

Direct Photocatalyzed Hydrogen Atom Transfer (HAT) for Aliphatic C–H Bonds Elaboration
por: Capaldo, Luca, et al.
Publicado: (2021)

Practical and Selective sp(3) C−H Bond Chlorination via Aminium Radicals
por: McMillan, Alastair J., et al.
Publicado: (2021)

Formation of a C–C double bond from two aliphatic carbons. Multiple C–H activations in an iridium pincer complex
por: Polukeev, Alexey V., et al.
Publicado: (2015)

Oxalyl amide assisted palladium-catalyzed synthesis of pyrrolidones via carbonylation of γ-C(sp(3))–H bonds of aliphatic amine substrates
por: Wang, Chao, et al.
Publicado: (2015)

Palladium-catalysed enantio- and regioselective (3 + 2) cycloaddition reactions of sulfamidate imine-derived 1-azadienes towards spirocyclic cyclopentanes
por: Pham, Quoc Hoang, et al.
Publicado: (2023)

Ligand-assisted palladium-catalyzed C–H alkenylation of aliphatic amines for the synthesis of functionalized pyrrolidines
por: He, Chuan, et al.
Publicado: (2017)

Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
por: Zheng, Yang, et al.
Publicado: (2015)

Chemoselective Aliphatic C–H Bond Oxidation Enabled by Polarity Reversal
por: Dantignana, Valeria, et al.
Publicado: (2017)

Hydroxy-directed fluorination of remote unactivated C(sp(3))–H bonds: a new age of diastereoselective radical fluorination
por: Harry, Stefan Andrew, et al.
Publicado: (2022)

Experimental evidence that halogen bonding catalyzes the heterogeneous chlorination of alkenes in submicron liquid droplets
por: Zeng, Meirong, et al.
Publicado: (2021)

Electron Fluxes in Biocathode Bioelectrochemical Systems Performing Dechlorination of Chlorinated Aliphatic Hydrocarbons
por: Chen, Fan, et al.
Publicado: (2018)

Radical-mediated direct C–H amination of arenes with secondary amines
por: Cosgrove, Sebastian C., et al.
Publicado: (2018)

Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams
por: Png, Zhuang Mao, et al.
Publicado: (2018)

Selective editing of a peptide skeleton via C–N bond formation at N-terminal aliphatic side chains
por: Han, Yujie, et al.
Publicado: (2022)

Functionalized aliphatic polyketones with germicide activity
por: Araya-Hermosilla, Esteban, et al.
Publicado: (2022)

Enantioselective intramolecular C–H amination of aliphatic azides by dual ruthenium and phosphine catalysis
por: Qin, Jie, et al.
Publicado: (2019)

Benchmark calculations for bond dissociation energies and enthalpy of formation of chlorinated and brominated polycyclic aromatic hydrocarbons
por: Xu, Shenying, et al.
Publicado: (2021)

Aromatic and aliphatic hydrocarbon hydroxylation via a formally Ni(IV)[double bond, length as m-dash]O oxidant
por: Heim, Philipp, et al.
Publicado: (2023)

Enzymatic Hydroxylation of Aliphatic C-H Bonds by a Mn/Fe Cofactor
por: Powell, Magan M., et al.
Publicado: (2023)

Enzymatic Hydroxylation of Aliphatic C–H Bonds by a Mn/Fe Cofactor
por: Powell, Magan M., et al.
Publicado: (2023)

Metal-free direct alkylation of unfunctionalized allylic/benzylic sp(3) C–H bonds via photoredox induced radical cation deprotonation
por: Zhou, Rong, et al.
Publicado: (2017)

Unstrained C–C bond activation and directed fluorination through photocatalytically-generated radical cations
por: Pitts, Cody Ross, et al.
Publicado: (2015)

Nickel-catalyzed transamidation of aliphatic amide derivatives
por: Dander, Jacob E., et al.
Publicado: (2017)

Growth factor loading on aliphatic polyester scaffolds
por: Shen, Hong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kqs711gv3u7q9fqtqq8n2av0nn