Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures

A highly efficient method for controllable double CF(2)-insertion into pentafluorophenylcopper species using TMSCF(3) as difluoromethylene source has been developed. The newly generated fluoroalkylcopper(i) species, C(6)F(5)CF(2)CF(2)Cu, shows good reactivity towards a myriad of structurally diverse...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Qiqiang, Zhu, Ziyue, Li, Lingchun, Ni, Chuanfa, Hu, Jinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133001/
https://www.ncbi.nlm.nih.gov/pubmed/34040722
http://dx.doi.org/10.1039/c9sc05018c
_version_ 1783695003293319168
author Xie, Qiqiang
Zhu, Ziyue
Li, Lingchun
Ni, Chuanfa
Hu, Jinbo
author_facet Xie, Qiqiang
Zhu, Ziyue
Li, Lingchun
Ni, Chuanfa
Hu, Jinbo
author_sort Xie, Qiqiang
collection PubMed
description A highly efficient method for controllable double CF(2)-insertion into pentafluorophenylcopper species using TMSCF(3) as difluoromethylene source has been developed. The newly generated fluoroalkylcopper(i) species, C(6)F(5)CF(2)CF(2)Cu, shows good reactivity towards a myriad of structurally diverse aryl, heteroaryl and alkenyl iodides. This protocol is easy to handle, ready to scale up and applicable for the synthesis of relative complex molecules, thus providing a convenient method for facile access to tetrafluoroethylene-bridged structures.
format Online
Article
Text
id pubmed-8133001
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-81330012021-05-25 Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures Xie, Qiqiang Zhu, Ziyue Li, Lingchun Ni, Chuanfa Hu, Jinbo Chem Sci Chemistry A highly efficient method for controllable double CF(2)-insertion into pentafluorophenylcopper species using TMSCF(3) as difluoromethylene source has been developed. The newly generated fluoroalkylcopper(i) species, C(6)F(5)CF(2)CF(2)Cu, shows good reactivity towards a myriad of structurally diverse aryl, heteroaryl and alkenyl iodides. This protocol is easy to handle, ready to scale up and applicable for the synthesis of relative complex molecules, thus providing a convenient method for facile access to tetrafluoroethylene-bridged structures. The Royal Society of Chemistry 2019-11-11 /pmc/articles/PMC8133001/ /pubmed/34040722 http://dx.doi.org/10.1039/c9sc05018c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xie, Qiqiang
Zhu, Ziyue
Li, Lingchun
Ni, Chuanfa
Hu, Jinbo
Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures
title Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures
title_full Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures
title_fullStr Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures
title_full_unstemmed Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures
title_short Controllable double CF(2)-insertion into sp(2) C–Cu bond using TMSCF(3): a facile access to tetrafluoroethylene-bridged structures
title_sort controllable double cf(2)-insertion into sp(2) c–cu bond using tmscf(3): a facile access to tetrafluoroethylene-bridged structures
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133001/
https://www.ncbi.nlm.nih.gov/pubmed/34040722
http://dx.doi.org/10.1039/c9sc05018c
work_keys_str_mv AT xieqiqiang controllabledoublecf2insertionintosp2ccubondusingtmscf3afacileaccesstotetrafluoroethylenebridgedstructures
AT zhuziyue controllabledoublecf2insertionintosp2ccubondusingtmscf3afacileaccesstotetrafluoroethylenebridgedstructures
AT lilingchun controllabledoublecf2insertionintosp2ccubondusingtmscf3afacileaccesstotetrafluoroethylenebridgedstructures
AT nichuanfa controllabledoublecf2insertionintosp2ccubondusingtmscf3afacileaccesstotetrafluoroethylenebridgedstructures
AT hujinbo controllabledoublecf2insertionintosp2ccubondusingtmscf3afacileaccesstotetrafluoroethylenebridgedstructures

Ejemplares similares