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Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review

RATIONALE: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. PATIENT CONCERNS: Here, we report a patient with primary YST in the pineal region who achieved long term...

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Autores principales: Xu, Zhen-Ning, Yue, Xiang-Yong, Cao, Xiao-Ci, Liu, Ya-Dong, Fang, Bao-Shuan, Zhao, Wen-Hao, Li, Chen, Xu, Shuai, Zhang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133229/
https://www.ncbi.nlm.nih.gov/pubmed/34106610
http://dx.doi.org/10.1097/MD.0000000000025778
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author Xu, Zhen-Ning
Yue, Xiang-Yong
Cao, Xiao-Ci
Liu, Ya-Dong
Fang, Bao-Shuan
Zhao, Wen-Hao
Li, Chen
Xu, Shuai
Zhang, Ming
author_facet Xu, Zhen-Ning
Yue, Xiang-Yong
Cao, Xiao-Ci
Liu, Ya-Dong
Fang, Bao-Shuan
Zhao, Wen-Hao
Li, Chen
Xu, Shuai
Zhang, Ming
author_sort Xu, Zhen-Ning
collection PubMed
description RATIONALE: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. PATIENT CONCERNS: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period. DIAGNOSIS: Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histological diagnosis suggested an intracranial YST. INTERVENTIONS: The patient achieved long term survival after combined modality therapy including surgery, stereotactic radiosurgery (SRS)/intensity modulated radiation therapy (IMRT), chemotherapy, and targeted therapy. OUTCOMES: The disease remained stable. However, the patient gave up treatment and passed away in October 2020, with a total survival of about 15 years. LESSONS: To the best of our knowledge, this patient with intracranial YST had received a longer survival compared with other published reports. We summarize previously published reports of intracranial YST and discuss the importance of multidisciplinary treatment. SRS may have a role, as a focal boost to residual tumor after resection or in case of recurrence after conventional radiotherapy, in the multimodality management of intracranial YSTs.
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spelling pubmed-81332292021-05-24 Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review Xu, Zhen-Ning Yue, Xiang-Yong Cao, Xiao-Ci Liu, Ya-Dong Fang, Bao-Shuan Zhao, Wen-Hao Li, Chen Xu, Shuai Zhang, Ming Medicine (Baltimore) 5700 RATIONALE: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. PATIENT CONCERNS: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period. DIAGNOSIS: Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histological diagnosis suggested an intracranial YST. INTERVENTIONS: The patient achieved long term survival after combined modality therapy including surgery, stereotactic radiosurgery (SRS)/intensity modulated radiation therapy (IMRT), chemotherapy, and targeted therapy. OUTCOMES: The disease remained stable. However, the patient gave up treatment and passed away in October 2020, with a total survival of about 15 years. LESSONS: To the best of our knowledge, this patient with intracranial YST had received a longer survival compared with other published reports. We summarize previously published reports of intracranial YST and discuss the importance of multidisciplinary treatment. SRS may have a role, as a focal boost to residual tumor after resection or in case of recurrence after conventional radiotherapy, in the multimodality management of intracranial YSTs. Lippincott Williams & Wilkins 2021-05-14 /pmc/articles/PMC8133229/ /pubmed/34106610 http://dx.doi.org/10.1097/MD.0000000000025778 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5700
Xu, Zhen-Ning
Yue, Xiang-Yong
Cao, Xiao-Ci
Liu, Ya-Dong
Fang, Bao-Shuan
Zhao, Wen-Hao
Li, Chen
Xu, Shuai
Zhang, Ming
Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
title Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
title_full Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
title_fullStr Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
title_full_unstemmed Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
title_short Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
title_sort multidisciplinary treatment of primary intracranial yolk sac tumor: a case report and literature review
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133229/
https://www.ncbi.nlm.nih.gov/pubmed/34106610
http://dx.doi.org/10.1097/MD.0000000000025778
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