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Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review
RATIONALE: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. PATIENT CONCERNS: Here, we report a patient with primary YST in the pineal region who achieved long term...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133229/ https://www.ncbi.nlm.nih.gov/pubmed/34106610 http://dx.doi.org/10.1097/MD.0000000000025778 |
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author | Xu, Zhen-Ning Yue, Xiang-Yong Cao, Xiao-Ci Liu, Ya-Dong Fang, Bao-Shuan Zhao, Wen-Hao Li, Chen Xu, Shuai Zhang, Ming |
author_facet | Xu, Zhen-Ning Yue, Xiang-Yong Cao, Xiao-Ci Liu, Ya-Dong Fang, Bao-Shuan Zhao, Wen-Hao Li, Chen Xu, Shuai Zhang, Ming |
author_sort | Xu, Zhen-Ning |
collection | PubMed |
description | RATIONALE: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. PATIENT CONCERNS: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period. DIAGNOSIS: Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histological diagnosis suggested an intracranial YST. INTERVENTIONS: The patient achieved long term survival after combined modality therapy including surgery, stereotactic radiosurgery (SRS)/intensity modulated radiation therapy (IMRT), chemotherapy, and targeted therapy. OUTCOMES: The disease remained stable. However, the patient gave up treatment and passed away in October 2020, with a total survival of about 15 years. LESSONS: To the best of our knowledge, this patient with intracranial YST had received a longer survival compared with other published reports. We summarize previously published reports of intracranial YST and discuss the importance of multidisciplinary treatment. SRS may have a role, as a focal boost to residual tumor after resection or in case of recurrence after conventional radiotherapy, in the multimodality management of intracranial YSTs. |
format | Online Article Text |
id | pubmed-8133229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-81332292021-05-24 Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review Xu, Zhen-Ning Yue, Xiang-Yong Cao, Xiao-Ci Liu, Ya-Dong Fang, Bao-Shuan Zhao, Wen-Hao Li, Chen Xu, Shuai Zhang, Ming Medicine (Baltimore) 5700 RATIONALE: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. PATIENT CONCERNS: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period. DIAGNOSIS: Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histological diagnosis suggested an intracranial YST. INTERVENTIONS: The patient achieved long term survival after combined modality therapy including surgery, stereotactic radiosurgery (SRS)/intensity modulated radiation therapy (IMRT), chemotherapy, and targeted therapy. OUTCOMES: The disease remained stable. However, the patient gave up treatment and passed away in October 2020, with a total survival of about 15 years. LESSONS: To the best of our knowledge, this patient with intracranial YST had received a longer survival compared with other published reports. We summarize previously published reports of intracranial YST and discuss the importance of multidisciplinary treatment. SRS may have a role, as a focal boost to residual tumor after resection or in case of recurrence after conventional radiotherapy, in the multimodality management of intracranial YSTs. Lippincott Williams & Wilkins 2021-05-14 /pmc/articles/PMC8133229/ /pubmed/34106610 http://dx.doi.org/10.1097/MD.0000000000025778 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 5700 Xu, Zhen-Ning Yue, Xiang-Yong Cao, Xiao-Ci Liu, Ya-Dong Fang, Bao-Shuan Zhao, Wen-Hao Li, Chen Xu, Shuai Zhang, Ming Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review |
title | Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review |
title_full | Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review |
title_fullStr | Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review |
title_full_unstemmed | Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review |
title_short | Multidisciplinary treatment of primary intracranial yolk sac tumor: A case report and literature review |
title_sort | multidisciplinary treatment of primary intracranial yolk sac tumor: a case report and literature review |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133229/ https://www.ncbi.nlm.nih.gov/pubmed/34106610 http://dx.doi.org/10.1097/MD.0000000000025778 |
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