Cargando…

Mesenchymal stromal cell delivery via an ex vivo bioreactor preclinical test system attenuates clot formation for intravascular application

While mesenchymal stromal cells are an appealing therapeutic option for a range of clinical applications, their potential to induce clotting when used systemically remains a safety concern, particularly in hypercoagulable conditions, such as in patients with severe COVID‐19, trauma, or cancers. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	O'Rourke, Brian, Nguyen, Sunny, Tilles, Arno W., Bynum, James A., Cap, Andrew P., Parekkadan, Biju, Barcia, Rita N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Enabling Technologies for Cell‐based Clinical Translation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133341/ https://www.ncbi.nlm.nih.gov/pubmed/33527780 http://dx.doi.org/10.1002/sctm.20-0454

Ejemplares similares

Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells
por: Allen, Ashley, et al.
Publicado: (2020)

Author Correction: Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells
por: Allen, Ashley, et al.
Publicado: (2020)

Independent, Controllable Stretch-Perfusion Bioreactor Chambers to Functionalize Cell-Seeded Decellularized Tendons
por: Talò, Giuseppe, et al.
Publicado: (2019)

Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing
por: Tanaka, Rica, et al.
Publicado: (2021)

Enabling Large‐Scale Ex Vivo Production of Megakaryocytes from CD34(+) Cells Using Gas‐Permeable Surfaces
por: Martinez, Andres F., et al.
Publicado: (2019)

Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection
por: Zhang, Y, et al.
Publicado: (2011)

Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells
por: Zhao, N, et al.
Publicado: (2011)

Concise Review: Skeletal Muscle as a Delivery Route for Mesenchymal Stromal Cells
por: Hamidian Jahromi, Shiva, et al.
Publicado: (2019)

Cross‐matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting
por: Rowland, Aileen L., et al.
Publicado: (2020)

Alterations in Hematopoietic and Mesenchymal Stromal Cell Components of the Osteopetrotic Bone Marrow Niche
por: Zeytin, Inci Cevher, et al.
Publicado: (2022)

Stem‐Cell Therapy for Esophageal Anastomotic Leakage by Autografting Stromal Cells in Fibrin Scaffold
por: Xue, Xiang, et al.
Publicado: (2019)

Resident vs nonresident multipotent mesenchymal stromal cell interactions with B lymphocytes result in disparate outcomes
por: Lee, Wei, et al.
Publicado: (2021)

Banking Mesenchymal Stromal Cells from Umbilical Cord Tissue: Large Sample Size Analysis Reveals Consistency Between Donors
por: Raileanu, Vanessa N., et al.
Publicado: (2019)

Single‐cell high‐content imaging parameters predict functional phenotype of cultured human bone marrow stromal stem cells
por: Kowal, Justyna M., et al.
Publicado: (2019)

A Pilot Phase I Trial of Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells in Neonates With Hypoxic-Ischemic Encephalopathy
por: Cotten, Charles Michael, et al.
Publicado: (2023)

Allogenic Umbilical Cord-Derived Mesenchymal Stromal Cells Sustain Long-Term Therapeutic Efficacy Compared With Low-Dose Interleukin-2 in Systemic Lupus Erythematosus
por: Cao, Zhouli, et al.
Publicado: (2023)

Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats
por: Arzi, Boaz, et al.
Publicado: (2016)

Development of a Functional Biomarker for Use in Cell-Based Therapy Studies in Seropositive Rheumatoid Arthritis
por: Shalev-Malul, Gali, et al.
Publicado: (2016)

CD11b+ and Sca-1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow-Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation
por: Cruz, Fernanda F., et al.
Publicado: (2016)

Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three-Dimensional Cryo-Imaging After Intravenous Infusion in a Rat Lung Injury Model
por: Schmuck, Eric G., et al.
Publicado: (2016)

Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through α(2)β(1) Signaling
por: Murphy, Kaitlin C., et al.
Publicado: (2016)

Perfluorocarbon Labeling of Human Glial‐Restricted Progenitors for (19)F Magnetic Resonance Imaging
por: Richard, Jean‐Philippe, et al.
Publicado: (2019)

Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell‐Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury
por: Kojima, Kota, et al.
Publicado: (2018)

Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual‐Center Study Using Adherent Vitrification
por: Kaindl, Johanna, et al.
Publicado: (2018)

Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches
por: Moshref, Maryam, et al.
Publicado: (2019)

Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age‐Related Macular Degeneration
por: Zarbin, Marco, et al.
Publicado: (2019)

Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels
por: Ho, Steve S., et al.
Publicado: (2016)

Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo
por: Trump, Lisa R., et al.
Publicado: (2019)

Viral pandemic preparedness: A pluripotent stem cell‐based machine‐learning platform for simulating SARS‐CoV‐2 infection to enable drug discovery and repurposing
por: Esmail, Sally, et al.
Publicado: (2020)

Propagation of human prostate tissue from induced pluripotent stem cells
por: Hepburn, Anastasia C., et al.
Publicado: (2020)

CRISPR/Cas9‐mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes
por: Ostrominski, John W., et al.
Publicado: (2020)

Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell‐based therapy
por: Sirish, Padmini, et al.
Publicado: (2020)

Concise Review: Boosting T‐Cell Reconstitution Following Allogeneic Transplantation—Current Concepts and Future Perspectives
por: Simons, Laura, et al.
Publicado: (2019)

Cardiac Regeneration by Statin‐Polymer Nanoparticle‐Loaded Adipose‐Derived Stem Cell Therapy in Myocardial Infarction
por: Yokoyama, Ryo, et al.
Publicado: (2019)

Translating intracarotid artery transplantation of bone marrow‐derived NCS‐01 cells for ischemic stroke: Behavioral and histological readouts and mechanistic insights into stem cell therapy
por: Kaneko, Yuji, et al.
Publicado: (2019)

Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats
por: Marsala, Martin, et al.
Publicado: (2019)

In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell‐derived neural stem/progenitor cells transplantation
por: Tanimoto, Yuji, et al.
Publicado: (2020)

Ventricular remodeling in ischemic heart failure stratifies responders to stem cell therapy
por: Yamada, Satsuki, et al.
Publicado: (2019)

Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle‐Mediated Delivery of miRNA
por: Shojaati, Golnar, et al.
Publicado: (2019)

A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury
por: Kamata, Yasuhiro, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o6a8j1ap4utd3cbu4vehc65klv