Cargando…

Development of an optimized and scalable method for isolation of umbilical cord blood‐derived small extracellular vesicles for future clinical use

Extracellular vesicles (EV) are a promising therapeutic tool in regenerative medicine. These particles were shown to accelerate wound healing, through delivery of regenerative mediators, such as microRNAs. Herein we describe an optimized and upscalable process for the isolation of EV smaller than 20...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cardoso, Renato M. S., Rodrigues, Silvia C., Gomes, Claudia F., Duarte, Filipe V., Romao, Maryse, Leal, Ermelindo C., Freire, Patricia C., Neves, Ricardo, Simões‐Correia, Joana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Manufacturing for Regenerative Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133342/ https://www.ncbi.nlm.nih.gov/pubmed/33577723 http://dx.doi.org/10.1002/sctm.20-0376

Ejemplares similares

Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles
por: Rodrigues, Silvia C., et al.
Publicado: (2021)

Production of Mesenchymal Progenitor Cell-Derived Extracellular Vesicles in Suspension Bioreactors for Use in Articular Cartilage Repair
por: Phelps, Jolene, et al.
Publicado: (2022)

Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders
por: Rodrigues, Sílvia C., et al.
Publicado: (2021)

Design and Validation of an Automated Process for the Expansion of Peripheral Blood‐Derived CD34(+) Cells for Clinical Use After Myocardial Infarction
por: Saucourt, Claire, et al.
Publicado: (2019)

Human Platelet Lysate Improves Bone Forming Potential of Human Progenitor Cells Expanded in Microcarrier‐Based Dynamic Culture
por: Gupta, Priyanka, et al.
Publicado: (2019)

Optimized serial expansion of human induced pluripotent stem cells using low‐density inoculation to generate clinically relevant quantities in vertical‐wheel bioreactors
por: Borys, Breanna S., et al.
Publicado: (2020)

Preclinical safety studies of human embryonic stem cell‐derived retinal pigment epithelial cells for the treatment of age‐related macular degeneration
por: Petrus‐Reurer, Sandra, et al.
Publicado: (2020)

Mesenchymal stromal cells pretreated with pro‐inflammatory cytokines promote skin wound healing through VEGFC‐mediated angiogenesis
por: Zhu, Mengting, et al.
Publicado: (2020)

Coadministration of endothelial and smooth muscle cells derived from human induced pluripotent stem cells as a therapy for critical limb ischemia
por: Park, Jin Ju, et al.
Publicado: (2020)

Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow‐up
por: Mizuno, Mitsuru, et al.
Publicado: (2021)

Facile bead‐to‐bead cell‐transfer method for serial subculture and large‐scale expansion of human mesenchymal stem cells in bioreactors
por: Chen, Shangwu, et al.
Publicado: (2021)

ID1/ID3 mediate the contribution of skin fibroblasts to local nerve regeneration through Itga6 in wound repair
por: Chen, Zelin, et al.
Publicado: (2021)

High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling
por: Manstein, Felix, et al.
Publicado: (2021)

Chemokine Assay Matrix Defines the Potency of Human Bone Marrow Mesenchymal Stromal Cells
por: Lipat, Ariel Joy, et al.
Publicado: (2022)

Lipidomics of Cell Secretome Combined with the Study of Selected Bioactive Lipids in an In Vitro Model of Osteoarthritis
por: Casati, Sara, et al.
Publicado: (2022)

Dll4 Inhibition Promotes Graft Retention in Fat Grafting Enriched with Adipose-Derived Stem Cells
por: Lee, Choong-kun, et al.
Publicado: (2022)

A Novel Approach for Determining the Critical Quality Attributes of Mesenchymal Stem Cells by Specifying Cell Population With Replication Potential
por: Yamamoto, Takako, et al.
Publicado: (2023)

Single-Cell RNA-Seq Reveals LRRC75A-Expressing Cell Population Involved in VEGF Secretion of Multipotent Mesenchymal Stromal/Stem Cells Under Ischemia
por: Miura, Takumi, et al.
Publicado: (2023)

Transplantation of hESCs-Derived Neural Progenitor Cells Alleviates Secondary Damage of Thalamus After Focal Cerebral Infarction in Rats
por: Li, Kongping, et al.
Publicado: (2023)

Expanded Access Protocol of Umbilical Cord Blood Infusion for Children with Neurological Conditions: An Update
por: McLaughlin, Colleen, et al.
Publicado: (2021)

Abstract 16 Insights into Highly Engraftable Hematopoietic Cells from 27-Year Cryopreserved Umbilical Cord Blood
por: Broxmeyer, Hal, et al.
Publicado: (2023)

Abstract 11 Outcome of Patients Treated with Umbilical Cord Blood and Homologous Serum Eye Drops
por: Buzzi, Marina, et al.
Publicado: (2022)

Extracellular Vesicle‐Educated Macrophages Promote Early Achilles Tendon Healing
por: Chamberlain, Connie S., et al.
Publicado: (2019)

Abstract 13 A Randomized, Placebo-Controlled, Phase II Trial of Intravenous Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke
por: Laskowitz, Daniel, et al.
Publicado: (2022)

Abstract 14 Umbilical Cord Mesenchymal Stromal/Stem Cells Application for Spasticity Treatment in Multiple Sclerosis
por: Petriv, Taras, et al.
Publicado: (2022)

Abstract 17 Umbilical Cord Blood Collection. How Do Different Factors Affect CD45 Cell Viability in Our Experience?
por: Gonel, Lorena, et al.
Publicado: (2023)

Injectable Amniotic Membrane/Umbilical Cord Particulate for Knee Osteoarthritis: A Prospective, Single-Center Pilot Study
por: Castellanos, Ramon, et al.
Publicado: (2019)

Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells
por: Liu, Senquan, et al.
Publicado: (2019)

Abstract 6 Combined Umbilical Cord Mesenchymal Stromal/Stem Cell Application For Primary Torsion Dystonia Treatment (Case Report)
por: Petriv, Taras, et al.
Publicado: (2023)

Role of Keratinocyte Growth Factor in the Differentiation of Sweat Gland-Like Cells From Human Umbilical Cord-Derived Mesenchymal Stem Cells
por: Xu, Yongan, et al.
Publicado: (2016)

Abstract 5 Umbilical Cord Blood Treatment to Improve Gross Motor Function in Individuals with Cerebral Palsy: Results from an Individual Participant Data Meta-Analysis
por: Finch-Edmondson, Megan, et al.
Publicado: (2023)

Ambulance location and relocation problems with time-dependent travel times
por: Schmid, Verena, et al.
Publicado: (2010)

Metal fused filament fabrication of the nickel-base superalloy IN 718
por: Thompson, Yvonne, et al.
Publicado: (2022)

External Application of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Hyaluronic Acid Gel Repairs Foot Wounds of Types I and II Diabetic Rats Through Paracrine Action Mode
por: Chen, Jingan, et al.
Publicado: (2023)

Mechanosensitive regulation of stanniocalcin‐1 by zyxin and actin‐myosin in human mesenchymal stromal cells
por: Zonderland, Jip, et al.
Publicado: (2020)

Stem Cells and Cartilage Development: Complexities of a Simple Tissue
por: Hollander, Anthony P, et al.
Publicado: (2010)

A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers
por: Rogers, Robert E., et al.
Publicado: (2021)

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation
por: Tassoni, Alessia, et al.
Publicado: (2015)

HC‐HA/PTX3 from amniotic membrane reverts senescent limbal niche cells to Pax6+ neural crest progenitors to support limbal epithelial progenitors
por: Chen, Szu‐Yu, et al.
Publicado: (2021)

Kidney Organoids Are Capable of Forming Tumors, but Not Teratomas
por: Shankar, Anusha S, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uec76euml6cr7k58f4r1ulg36p