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Parkinson’s disease case ascertainment in a large prospective cohort

BACKGROUND: In epidemiologic studies where physician-based case adjudication is not feasible, Parkinson’s disease (PD) case ascertainment is often limited to self-reports which may not be accurate. We evaluated strategies to identify PD cases in the Agricultural Health Study (AHS). METHODS: Doctor-d...

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Autores principales: Shrestha, Srishti, Parks, Christine G., Richards-Barber, Marie, Chen, Honglei, Sandler, Dale P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133399/
https://www.ncbi.nlm.nih.gov/pubmed/34010345
http://dx.doi.org/10.1371/journal.pone.0251852
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author Shrestha, Srishti
Parks, Christine G.
Richards-Barber, Marie
Chen, Honglei
Sandler, Dale P.
author_facet Shrestha, Srishti
Parks, Christine G.
Richards-Barber, Marie
Chen, Honglei
Sandler, Dale P.
author_sort Shrestha, Srishti
collection PubMed
description BACKGROUND: In epidemiologic studies where physician-based case adjudication is not feasible, Parkinson’s disease (PD) case ascertainment is often limited to self-reports which may not be accurate. We evaluated strategies to identify PD cases in the Agricultural Health Study (AHS). METHODS: Doctor-diagnosed PD was self-reported on all cohort-wide surveys; potential cases were also identified from death certificates. Follow-up surveys asked about PD-related motor and non-motor symptoms. For PD confirmation, we collected additional diagnosis, symptom, and treatment data from 510 potential PD cases or their proxy (65% of those contacted) in a supplemental screener and obtained medical records for a subset (n = 65). We classified PD cases using established criteria and screener data. RESULTS: Of 510 potential PD cases, 75% were considered “probable” or “possible”; this proportion increased among participants diagnosed by a specialist (81.2%), taking PD medication (85.2%), or reporting ≥5 motor symptoms (86.8%) in a regular AHS survey. Of those with medical records, 93% (57 of 61) of probable or possible PD was confirmed. Never-smoking and non-motor and motor symptoms reported in prior AHS surveys were more common with probable/possible PD than unconfirmed PD. CONCLUSION: In this retrospective PD case ascertainment effort, we found that PD self-report with information on motor symptoms or medications may be a reasonable alternative for identifying PD cases when physician exam is not feasible. Because of intervening mortality, screeners could not be obtained from about one-third of those contacted. Thus, findings warrant replication.
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spelling pubmed-81333992021-05-27 Parkinson’s disease case ascertainment in a large prospective cohort Shrestha, Srishti Parks, Christine G. Richards-Barber, Marie Chen, Honglei Sandler, Dale P. PLoS One Research Article BACKGROUND: In epidemiologic studies where physician-based case adjudication is not feasible, Parkinson’s disease (PD) case ascertainment is often limited to self-reports which may not be accurate. We evaluated strategies to identify PD cases in the Agricultural Health Study (AHS). METHODS: Doctor-diagnosed PD was self-reported on all cohort-wide surveys; potential cases were also identified from death certificates. Follow-up surveys asked about PD-related motor and non-motor symptoms. For PD confirmation, we collected additional diagnosis, symptom, and treatment data from 510 potential PD cases or their proxy (65% of those contacted) in a supplemental screener and obtained medical records for a subset (n = 65). We classified PD cases using established criteria and screener data. RESULTS: Of 510 potential PD cases, 75% were considered “probable” or “possible”; this proportion increased among participants diagnosed by a specialist (81.2%), taking PD medication (85.2%), or reporting ≥5 motor symptoms (86.8%) in a regular AHS survey. Of those with medical records, 93% (57 of 61) of probable or possible PD was confirmed. Never-smoking and non-motor and motor symptoms reported in prior AHS surveys were more common with probable/possible PD than unconfirmed PD. CONCLUSION: In this retrospective PD case ascertainment effort, we found that PD self-report with information on motor symptoms or medications may be a reasonable alternative for identifying PD cases when physician exam is not feasible. Because of intervening mortality, screeners could not be obtained from about one-third of those contacted. Thus, findings warrant replication. Public Library of Science 2021-05-19 /pmc/articles/PMC8133399/ /pubmed/34010345 http://dx.doi.org/10.1371/journal.pone.0251852 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Shrestha, Srishti
Parks, Christine G.
Richards-Barber, Marie
Chen, Honglei
Sandler, Dale P.
Parkinson’s disease case ascertainment in a large prospective cohort
title Parkinson’s disease case ascertainment in a large prospective cohort
title_full Parkinson’s disease case ascertainment in a large prospective cohort
title_fullStr Parkinson’s disease case ascertainment in a large prospective cohort
title_full_unstemmed Parkinson’s disease case ascertainment in a large prospective cohort
title_short Parkinson’s disease case ascertainment in a large prospective cohort
title_sort parkinson’s disease case ascertainment in a large prospective cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133399/
https://www.ncbi.nlm.nih.gov/pubmed/34010345
http://dx.doi.org/10.1371/journal.pone.0251852
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