Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis

Methylation of the HLTF gene in colorectal cancer (CRC) cells occurs more frequently in men than women. Progressive epigenetic silencing of HLTF in tumor cells is accompanied by negligible expression in the tumor microenvironment (TME). Cell line-derived xenografts (CDX) were established in control...

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Detalles Bibliográficos
Autores principales: Helmer, Rebecca A., Martinez-Zaguilan, Raul, Kaur, Gurvinder, Smith, Lisa A., Dufour, Jannette M., Chilton, Beverly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133447/
https://www.ncbi.nlm.nih.gov/pubmed/34010296
http://dx.doi.org/10.1371/journal.pone.0251132

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