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Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining

We study the effects of two mechanisms which increase the efficacy of contact-tracing applications (CTAs) such as the mobile phone contact-tracing applications that have been used during the COVID-19 epidemic. The first mechanism is the introduction of user referrals. We compare four scenarios for t...

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Autores principales: Goldberg, Leslie Ann, Jorritsma, Joost, Komjáthy, Júlia, Lapinskas, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133478/
https://www.ncbi.nlm.nih.gov/pubmed/34010333
http://dx.doi.org/10.1371/journal.pone.0250435
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author Goldberg, Leslie Ann
Jorritsma, Joost
Komjáthy, Júlia
Lapinskas, John
author_facet Goldberg, Leslie Ann
Jorritsma, Joost
Komjáthy, Júlia
Lapinskas, John
author_sort Goldberg, Leslie Ann
collection PubMed
description We study the effects of two mechanisms which increase the efficacy of contact-tracing applications (CTAs) such as the mobile phone contact-tracing applications that have been used during the COVID-19 epidemic. The first mechanism is the introduction of user referrals. We compare four scenarios for the uptake of CTAs—(1) the p% of individuals that use the CTA are chosen randomly, (2) a smaller initial set of randomly-chosen users each refer a contact to use the CTA, achieving p% in total, (3) a small initial set of randomly-chosen users each refer around half of their contacts to use the CTA, achieving p% in total, and (4) for comparison, an idealised scenario in which the p% of the population that uses the CTA is the p% with the most contacts. Using agent-based epidemiological models incorporating a geometric space, we find that, even when the uptake percentage p% is small, CTAs are an effective tool for mitigating the spread of the epidemic in all scenarios. Moreover, user referrals significantly improve efficacy. In addition, it turns out that user referrals reduce the quarantine load. The second mechanism for increasing the efficacy of CTAs is tuning the severity of quarantine measures. Our modelling shows that using CTAs with mild quarantine measures is effective in reducing the maximum hospital load and the number of people who become ill, but leads to a relatively high quarantine load, which may cause economic disruption. Fortunately, under stricter quarantine measures, the advantages are maintained but the quarantine load is reduced. Our models incorporate geometric inhomogeneous random graphs to study the effects of the presence of super-spreaders and of the absence of long-distant contacts (e.g., through travel restrictions) on our conclusions.
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spelling pubmed-81334782021-05-27 Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining Goldberg, Leslie Ann Jorritsma, Joost Komjáthy, Júlia Lapinskas, John PLoS One Research Article We study the effects of two mechanisms which increase the efficacy of contact-tracing applications (CTAs) such as the mobile phone contact-tracing applications that have been used during the COVID-19 epidemic. The first mechanism is the introduction of user referrals. We compare four scenarios for the uptake of CTAs—(1) the p% of individuals that use the CTA are chosen randomly, (2) a smaller initial set of randomly-chosen users each refer a contact to use the CTA, achieving p% in total, (3) a small initial set of randomly-chosen users each refer around half of their contacts to use the CTA, achieving p% in total, and (4) for comparison, an idealised scenario in which the p% of the population that uses the CTA is the p% with the most contacts. Using agent-based epidemiological models incorporating a geometric space, we find that, even when the uptake percentage p% is small, CTAs are an effective tool for mitigating the spread of the epidemic in all scenarios. Moreover, user referrals significantly improve efficacy. In addition, it turns out that user referrals reduce the quarantine load. The second mechanism for increasing the efficacy of CTAs is tuning the severity of quarantine measures. Our modelling shows that using CTAs with mild quarantine measures is effective in reducing the maximum hospital load and the number of people who become ill, but leads to a relatively high quarantine load, which may cause economic disruption. Fortunately, under stricter quarantine measures, the advantages are maintained but the quarantine load is reduced. Our models incorporate geometric inhomogeneous random graphs to study the effects of the presence of super-spreaders and of the absence of long-distant contacts (e.g., through travel restrictions) on our conclusions. Public Library of Science 2021-05-19 /pmc/articles/PMC8133478/ /pubmed/34010333 http://dx.doi.org/10.1371/journal.pone.0250435 Text en © 2021 Goldberg et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Goldberg, Leslie Ann
Jorritsma, Joost
Komjáthy, Júlia
Lapinskas, John
Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
title Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
title_full Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
title_fullStr Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
title_full_unstemmed Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
title_short Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
title_sort increasing efficacy of contact-tracing applications by user referrals and stricter quarantining
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133478/
https://www.ncbi.nlm.nih.gov/pubmed/34010333
http://dx.doi.org/10.1371/journal.pone.0250435
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