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Geometry and cellular function of organelle membrane interfaces

A vast majority of cellular processes take root at the surface of biological membranes. By providing a two-dimensional platform with limited diffusion, membranes are, by nature, perfect devices to concentrate signaling and metabolic components. As such, membranes often act as “key processors” of cel...

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Detalles Bibliográficos
Autores principales: Rosado, Abel, Bayer, Emmanuelle M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133572/
https://www.ncbi.nlm.nih.gov/pubmed/33793898
http://dx.doi.org/10.1093/plphys/kiaa079
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author Rosado, Abel
Bayer, Emmanuelle M
author_facet Rosado, Abel
Bayer, Emmanuelle M
author_sort Rosado, Abel
collection PubMed
description A vast majority of cellular processes take root at the surface of biological membranes. By providing a two-dimensional platform with limited diffusion, membranes are, by nature, perfect devices to concentrate signaling and metabolic components. As such, membranes often act as “key processors” of cellular information. Biological membranes are highly dynamic and deformable and can be shaped into curved, tubular, or flat conformations, resulting in differentiated biophysical properties. At membrane contact sites, membranes from adjacent organelles come together into a unique 3D configuration, forming functionally distinct microdomains, which facilitate spatially regulated functions, such as organelle communication. Here, we describe the diversity of geometries of contact site-forming membranes in different eukaryotic organisms and explore the emerging notion that their shape, 3D architecture, and remodeling jointly define their cellular activity. The review also provides selected examples highlighting changes in membrane contact site architecture acting as rapid and local responses to cellular perturbations, and summarizes our current understanding of how those structural changes confer functional specificity to those cellular territories.
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spelling pubmed-81335722021-05-25 Geometry and cellular function of organelle membrane interfaces Rosado, Abel Bayer, Emmanuelle M Plant Physiol Focus Issue on Dynamic Membranes A vast majority of cellular processes take root at the surface of biological membranes. By providing a two-dimensional platform with limited diffusion, membranes are, by nature, perfect devices to concentrate signaling and metabolic components. As such, membranes often act as “key processors” of cellular information. Biological membranes are highly dynamic and deformable and can be shaped into curved, tubular, or flat conformations, resulting in differentiated biophysical properties. At membrane contact sites, membranes from adjacent organelles come together into a unique 3D configuration, forming functionally distinct microdomains, which facilitate spatially regulated functions, such as organelle communication. Here, we describe the diversity of geometries of contact site-forming membranes in different eukaryotic organisms and explore the emerging notion that their shape, 3D architecture, and remodeling jointly define their cellular activity. The review also provides selected examples highlighting changes in membrane contact site architecture acting as rapid and local responses to cellular perturbations, and summarizes our current understanding of how those structural changes confer functional specificity to those cellular territories. Oxford University Press 2020-12-29 /pmc/articles/PMC8133572/ /pubmed/33793898 http://dx.doi.org/10.1093/plphys/kiaa079 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of American Society of Plant Biologists. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Focus Issue on Dynamic Membranes
Rosado, Abel
Bayer, Emmanuelle M
Geometry and cellular function of organelle membrane interfaces
title Geometry and cellular function of organelle membrane interfaces
title_full Geometry and cellular function of organelle membrane interfaces
title_fullStr Geometry and cellular function of organelle membrane interfaces
title_full_unstemmed Geometry and cellular function of organelle membrane interfaces
title_short Geometry and cellular function of organelle membrane interfaces
title_sort geometry and cellular function of organelle membrane interfaces
topic Focus Issue on Dynamic Membranes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133572/
https://www.ncbi.nlm.nih.gov/pubmed/33793898
http://dx.doi.org/10.1093/plphys/kiaa079
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