Preservation of lagging strand integrity at sites of stalled replication by Pol α-primase and 9-1-1 complex

During genome duplication, the replication fork encounters a plethora of obstacles in the form of damaged bases, DNA–cross-linked proteins, and secondary structures. How cells protect DNA integrity at sites of stalled replication is currently unknown. Here, by engineering “primase deserts” into the...

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Detalles Bibliográficos
Autores principales: van Schendel, Robin, Romeijn, Ron, Buijs, Helena, Tijsterman, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133754/
https://www.ncbi.nlm.nih.gov/pubmed/34138739
http://dx.doi.org/10.1126/sciadv.abf2278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133754/
https://www.ncbi.nlm.nih.gov/pubmed/34138739
http://dx.doi.org/10.1126/sciadv.abf2278

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