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Preservation of lagging strand integrity at sites of stalled replication by Pol α-primase and 9-1-1 complex
During genome duplication, the replication fork encounters a plethora of obstacles in the form of damaged bases, DNA–cross-linked proteins, and secondary structures. How cells protect DNA integrity at sites of stalled replication is currently unknown. Here, by engineering “primase deserts” into the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133754/ https://www.ncbi.nlm.nih.gov/pubmed/34138739 http://dx.doi.org/10.1126/sciadv.abf2278 |