Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer targets for decades. Six known binding sites on tubulin dimers have been identified thus far, with five sites on β-tubulin and only one site on α-tubulin, hinting that compounds binding to α-tubulin are less well cha...

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Detalles Bibliográficos
Autores principales: Yang, Jianhong, Yu, Yamei, Li, Yong, Yan, Wei, Ye, Haoyu, Niu, Lu, Tang, Minghai, Wang, Zhoufeng, Yang, Zhuang, Pei, Heying, Wei, Haoche, Zhao, Min, Wen, Jiaolin, Yang, Linyu, Ouyang, Liang, Wei, Yuquan, Chen, Qiang, Li, Weimin, Chen, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133757/
https://www.ncbi.nlm.nih.gov/pubmed/34138737
http://dx.doi.org/10.1126/sciadv.abg4168

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