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A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts

INTRODUCTION: Latin America accounts for one-quarter of global COVID-19 cases and one-third of deaths. Inequalities in the region lead to barriers to the best use of diagnostic tests during the pandemic. There is a need for simplified guidelines that consider the region’s limited health resources, i...

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Autores principales: Fay, Fabian F., Alvarez-Moreno, Carlos Arturo, Bonvehi, Pablo E., Espinoza, Carolina Cucho, Hidalgo, Marco Luis Herrera, Marcano-Lozada, Marcel, Perez, Carlos M., Pulchinelli Jr, Alvaro, Sáenz- Flor, Klever Vinicio, Condino-Neto, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133827/
https://www.ncbi.nlm.nih.gov/pubmed/34022333
http://dx.doi.org/10.1016/j.ijid.2021.05.011
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author Fay, Fabian F.
Alvarez-Moreno, Carlos Arturo
Bonvehi, Pablo E.
Espinoza, Carolina Cucho
Hidalgo, Marco Luis Herrera
Marcano-Lozada, Marcel
Perez, Carlos M.
Pulchinelli Jr, Alvaro
Sáenz- Flor, Klever Vinicio
Condino-Neto, Antonio
author_facet Fay, Fabian F.
Alvarez-Moreno, Carlos Arturo
Bonvehi, Pablo E.
Espinoza, Carolina Cucho
Hidalgo, Marco Luis Herrera
Marcano-Lozada, Marcel
Perez, Carlos M.
Pulchinelli Jr, Alvaro
Sáenz- Flor, Klever Vinicio
Condino-Neto, Antonio
author_sort Fay, Fabian F.
collection PubMed
description INTRODUCTION: Latin America accounts for one-quarter of global COVID-19 cases and one-third of deaths. Inequalities in the region lead to barriers to the best use of diagnostic tests during the pandemic. There is a need for simplified guidelines that consider the region’s limited health resources, international guidelines, medical literature, and local expertise. METHODS: Using a modified Delphi method, 9 experts from Latin American countries developed a simplified algorithm for COVID-19 diagnosis on the basis of their answers to 24 questions related to diagnostic settings, and discussion of the literature and their experiences. RESULTS: The algorithm considers 3 timeframes (≤7 days, 8–13 days, and ≥14 days) and presents diagnostic options for each. SARS-CoV-2 real- time reverse transcription-polymerase chain reaction is the test of choice from day 1 to 14 after symptom onset or close contact, although antigen testing may be used in specific circumstances, from day 5 to 7. Antibody assays may be used for confirmation, usually after day 14; however, if clinical suspicion is very high, but other tests are negative, these assays may be used as an adjunct to decision-making from day 8 to 13. CONCLUSION: The proposed algorithm aims to support COVID-19 diagnosis decision-making in Latin America.
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spelling pubmed-81338272021-05-20 A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts Fay, Fabian F. Alvarez-Moreno, Carlos Arturo Bonvehi, Pablo E. Espinoza, Carolina Cucho Hidalgo, Marco Luis Herrera Marcano-Lozada, Marcel Perez, Carlos M. Pulchinelli Jr, Alvaro Sáenz- Flor, Klever Vinicio Condino-Neto, Antonio Int J Infect Dis Article INTRODUCTION: Latin America accounts for one-quarter of global COVID-19 cases and one-third of deaths. Inequalities in the region lead to barriers to the best use of diagnostic tests during the pandemic. There is a need for simplified guidelines that consider the region’s limited health resources, international guidelines, medical literature, and local expertise. METHODS: Using a modified Delphi method, 9 experts from Latin American countries developed a simplified algorithm for COVID-19 diagnosis on the basis of their answers to 24 questions related to diagnostic settings, and discussion of the literature and their experiences. RESULTS: The algorithm considers 3 timeframes (≤7 days, 8–13 days, and ≥14 days) and presents diagnostic options for each. SARS-CoV-2 real- time reverse transcription-polymerase chain reaction is the test of choice from day 1 to 14 after symptom onset or close contact, although antigen testing may be used in specific circumstances, from day 5 to 7. Antibody assays may be used for confirmation, usually after day 14; however, if clinical suspicion is very high, but other tests are negative, these assays may be used as an adjunct to decision-making from day 8 to 13. CONCLUSION: The proposed algorithm aims to support COVID-19 diagnosis decision-making in Latin America. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-04 2021-05-20 /pmc/articles/PMC8133827/ /pubmed/34022333 http://dx.doi.org/10.1016/j.ijid.2021.05.011 Text en © 2021 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Fay, Fabian F.
Alvarez-Moreno, Carlos Arturo
Bonvehi, Pablo E.
Espinoza, Carolina Cucho
Hidalgo, Marco Luis Herrera
Marcano-Lozada, Marcel
Perez, Carlos M.
Pulchinelli Jr, Alvaro
Sáenz- Flor, Klever Vinicio
Condino-Neto, Antonio
A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts
title A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts
title_full A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts
title_fullStr A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts
title_full_unstemmed A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts
title_short A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts
title_sort simplified alternative diagnostic algorithm for sars-cov-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): a consensus of latin american experts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133827/
https://www.ncbi.nlm.nih.gov/pubmed/34022333
http://dx.doi.org/10.1016/j.ijid.2021.05.011
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