Cargando…

Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease

Sickle cell disease (SCD) is a well-characterized hemoglobinopathy affecting more than 20 million individuals worldwide and carries an increased risk of cerebral vasculopathy, cerebral infarct, and stroke. As mechanisms of cerebral infarction in SCD are partly attributable to microvascular vaso-occl...

Descripción completa

Detalles Bibliográficos
Autores principales: Justice, Olivia, Jordan, Lori C., Lee, Chelsea A., Patel, Niral J., Waddle, Spencer, Pruthi, Sumit, Davis, L. Taylor, Kassim, Adetola A., Donahue, Manus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133848/
https://www.ncbi.nlm.nih.gov/pubmed/34055410
http://dx.doi.org/10.1155/2021/5531775
_version_ 1783695132482076672
author Justice, Olivia
Jordan, Lori C.
Lee, Chelsea A.
Patel, Niral J.
Waddle, Spencer
Pruthi, Sumit
Davis, L. Taylor
Kassim, Adetola A.
Donahue, Manus J.
author_facet Justice, Olivia
Jordan, Lori C.
Lee, Chelsea A.
Patel, Niral J.
Waddle, Spencer
Pruthi, Sumit
Davis, L. Taylor
Kassim, Adetola A.
Donahue, Manus J.
author_sort Justice, Olivia
collection PubMed
description Sickle cell disease (SCD) is a well-characterized hemoglobinopathy affecting more than 20 million individuals worldwide and carries an increased risk of cerebral vasculopathy, cerebral infarct, and stroke. As mechanisms of cerebral infarction in SCD are partly attributable to microvascular vaso-occlusive crises, manifesting as altered cerebral blood flow and associated impaired oxygen delivery, magnetic resonance imaging (MRI) methods that can quickly provide a comprehensive perspective on structural and functional disease status, without exogenous contrast administration or ionizing radiation, have emerged as crucial clinical tools for surveillance. However, early ex vivo MRI work in suspended erythrocytes containing hemoglobin S at 0.35 Tesla (T) suggested that sickled erythrocytes can orient preferentially in the presence of an external magnetic field, and as such, it was suggested that MRI exams in sickle cell hemoglobinopathy could induce vaso-occlusion. While this observation has generally not impacted clinical imaging in individuals with SCD, it has led to resistance for some sickle cell studies within the engineering community among some imaging scientists as this early observation has never been rigorously shown to be unconcerning. Here, we performed MRI at the clinical field strength of 3 T in 172 patients with SCD, which included standard anatomical and angiographic assessments together with gold standard diffusion-weighted imaging (DWI; spatial resolution = 1.8 × 1.8 × 4 mm; b-value = 1000 s/mm(2)) for acute infarct assessment (performed approximately 20 min after patient introduction to the field isocenter). The presence of vasculopathy, as well as chronic and acute infarcts, was evaluated by two independent board-certified radiologists using standard clinical criteria. In these patients (52.3% female; mean age = 19.6 years; age range = 6–44 years), hematocrit (mean = 25.8%; range = 15–36%), hemoglobin phenotype (87.8% HbSS variant), presence of silent infarct (44.2%), and overt chronic infarct (13.4%) were consistent with a typical SCD population; however, no participants exhibited evidence of acute infarction. These findings are consistent with 3 T MRI not inducing acute infarction or vaso-occlusion in individuals with SCD and suggest that earlier low-field ex vivo work of erythrocytes in suspension is not a sufficient cause to discourage MRI scans in patients with SCD.
format Online
Article
Text
id pubmed-8133848
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-81338482021-05-27 Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease Justice, Olivia Jordan, Lori C. Lee, Chelsea A. Patel, Niral J. Waddle, Spencer Pruthi, Sumit Davis, L. Taylor Kassim, Adetola A. Donahue, Manus J. Radiol Res Pract Research Article Sickle cell disease (SCD) is a well-characterized hemoglobinopathy affecting more than 20 million individuals worldwide and carries an increased risk of cerebral vasculopathy, cerebral infarct, and stroke. As mechanisms of cerebral infarction in SCD are partly attributable to microvascular vaso-occlusive crises, manifesting as altered cerebral blood flow and associated impaired oxygen delivery, magnetic resonance imaging (MRI) methods that can quickly provide a comprehensive perspective on structural and functional disease status, without exogenous contrast administration or ionizing radiation, have emerged as crucial clinical tools for surveillance. However, early ex vivo MRI work in suspended erythrocytes containing hemoglobin S at 0.35 Tesla (T) suggested that sickled erythrocytes can orient preferentially in the presence of an external magnetic field, and as such, it was suggested that MRI exams in sickle cell hemoglobinopathy could induce vaso-occlusion. While this observation has generally not impacted clinical imaging in individuals with SCD, it has led to resistance for some sickle cell studies within the engineering community among some imaging scientists as this early observation has never been rigorously shown to be unconcerning. Here, we performed MRI at the clinical field strength of 3 T in 172 patients with SCD, which included standard anatomical and angiographic assessments together with gold standard diffusion-weighted imaging (DWI; spatial resolution = 1.8 × 1.8 × 4 mm; b-value = 1000 s/mm(2)) for acute infarct assessment (performed approximately 20 min after patient introduction to the field isocenter). The presence of vasculopathy, as well as chronic and acute infarcts, was evaluated by two independent board-certified radiologists using standard clinical criteria. In these patients (52.3% female; mean age = 19.6 years; age range = 6–44 years), hematocrit (mean = 25.8%; range = 15–36%), hemoglobin phenotype (87.8% HbSS variant), presence of silent infarct (44.2%), and overt chronic infarct (13.4%) were consistent with a typical SCD population; however, no participants exhibited evidence of acute infarction. These findings are consistent with 3 T MRI not inducing acute infarction or vaso-occlusion in individuals with SCD and suggest that earlier low-field ex vivo work of erythrocytes in suspension is not a sufficient cause to discourage MRI scans in patients with SCD. Hindawi 2021-05-11 /pmc/articles/PMC8133848/ /pubmed/34055410 http://dx.doi.org/10.1155/2021/5531775 Text en Copyright © 2021 Olivia Justice et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Justice, Olivia
Jordan, Lori C.
Lee, Chelsea A.
Patel, Niral J.
Waddle, Spencer
Pruthi, Sumit
Davis, L. Taylor
Kassim, Adetola A.
Donahue, Manus J.
Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease
title Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease
title_full Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease
title_fullStr Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease
title_full_unstemmed Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease
title_short Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease
title_sort safety of 3 tesla magnetic resonance imaging in patients with sickle cell disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133848/
https://www.ncbi.nlm.nih.gov/pubmed/34055410
http://dx.doi.org/10.1155/2021/5531775
work_keys_str_mv AT justiceolivia safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT jordanloric safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT leechelseaa safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT patelniralj safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT waddlespencer safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT pruthisumit safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT davisltaylor safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT kassimadetolaa safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease
AT donahuemanusj safetyof3teslamagneticresonanceimaginginpatientswithsicklecelldisease