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Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model
Yijin-tang is an oriental traditional herb used to treat inflammatory diseases. In the present study, we investigated the protective effects of Yijin-tang water extract (YTE) using an ovalbumin- (OVA-) induced asthma model, focusing on the antioxidant and anti-inflammatory properties of the herb. BA...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133850/ https://www.ncbi.nlm.nih.gov/pubmed/34055011 http://dx.doi.org/10.1155/2021/5585692 |
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author | Lee, Se-Jin Lee, A. Yeong Lim, Je-Oh Lee, Ji Hye Jung, Tae-Yang Pak, So-Won Kim, Woong-Il Seo, Yoon Soo Kim, Jong-Choon Ko, Je-Won Shin, In-Sik |
author_facet | Lee, Se-Jin Lee, A. Yeong Lim, Je-Oh Lee, Ji Hye Jung, Tae-Yang Pak, So-Won Kim, Woong-Il Seo, Yoon Soo Kim, Jong-Choon Ko, Je-Won Shin, In-Sik |
author_sort | Lee, Se-Jin |
collection | PubMed |
description | Yijin-tang is an oriental traditional herb used to treat inflammatory diseases. In the present study, we investigated the protective effects of Yijin-tang water extract (YTE) using an ovalbumin- (OVA-) induced asthma model, focusing on the antioxidant and anti-inflammatory properties of the herb. BALB/c mice were intraperitoneally injected with OVA on days 0 and 14 and then challenged with OVA on days 21, 22, and 23. The animals were orally administered YTE (200 and 400 mg/kg) from days 18 to 23, and this was found to significantly decrease airway hyperresponsiveness and release of inflammatory cells, cytokines, and OVA-specific immunoglobulin E in mice with asthma. In addition, YTE was associated with a marked reduction in airway inflammation and mucus production in lung tissue of mice with asthma. Furthermore, YTE suppressed the expression of matrix metalloproteinase-9 and phosphorylation of ERK in the lungs, which in turn led to a reduction in inducible nitric oxide synthases and an elevation in reduced glutathione and heme oxygenase-1. In conclusion, YTE effectively suppressed allergic responses in mice with asthma and the effect was closely related to antioxidant and anti-inflammatory properties of the herb. Our results indicate that YTE may be a potential agent for the treatment of allergic asthma. |
format | Online Article Text |
id | pubmed-8133850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-81338502021-05-27 Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model Lee, Se-Jin Lee, A. Yeong Lim, Je-Oh Lee, Ji Hye Jung, Tae-Yang Pak, So-Won Kim, Woong-Il Seo, Yoon Soo Kim, Jong-Choon Ko, Je-Won Shin, In-Sik Evid Based Complement Alternat Med Research Article Yijin-tang is an oriental traditional herb used to treat inflammatory diseases. In the present study, we investigated the protective effects of Yijin-tang water extract (YTE) using an ovalbumin- (OVA-) induced asthma model, focusing on the antioxidant and anti-inflammatory properties of the herb. BALB/c mice were intraperitoneally injected with OVA on days 0 and 14 and then challenged with OVA on days 21, 22, and 23. The animals were orally administered YTE (200 and 400 mg/kg) from days 18 to 23, and this was found to significantly decrease airway hyperresponsiveness and release of inflammatory cells, cytokines, and OVA-specific immunoglobulin E in mice with asthma. In addition, YTE was associated with a marked reduction in airway inflammation and mucus production in lung tissue of mice with asthma. Furthermore, YTE suppressed the expression of matrix metalloproteinase-9 and phosphorylation of ERK in the lungs, which in turn led to a reduction in inducible nitric oxide synthases and an elevation in reduced glutathione and heme oxygenase-1. In conclusion, YTE effectively suppressed allergic responses in mice with asthma and the effect was closely related to antioxidant and anti-inflammatory properties of the herb. Our results indicate that YTE may be a potential agent for the treatment of allergic asthma. Hindawi 2021-05-11 /pmc/articles/PMC8133850/ /pubmed/34055011 http://dx.doi.org/10.1155/2021/5585692 Text en Copyright © 2021 Se-Jin Lee et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lee, Se-Jin Lee, A. Yeong Lim, Je-Oh Lee, Ji Hye Jung, Tae-Yang Pak, So-Won Kim, Woong-Il Seo, Yoon Soo Kim, Jong-Choon Ko, Je-Won Shin, In-Sik Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model |
title | Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model |
title_full | Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model |
title_fullStr | Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model |
title_full_unstemmed | Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model |
title_short | Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model |
title_sort | effect of yijin-tang, an oriental traditional formula, on allergic responses using an ovalbumin-induced murine asthma model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133850/ https://www.ncbi.nlm.nih.gov/pubmed/34055011 http://dx.doi.org/10.1155/2021/5585692 |
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