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Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model

Yijin-tang is an oriental traditional herb used to treat inflammatory diseases. In the present study, we investigated the protective effects of Yijin-tang water extract (YTE) using an ovalbumin- (OVA-) induced asthma model, focusing on the antioxidant and anti-inflammatory properties of the herb. BA...

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Autores principales: Lee, Se-Jin, Lee, A. Yeong, Lim, Je-Oh, Lee, Ji Hye, Jung, Tae-Yang, Pak, So-Won, Kim, Woong-Il, Seo, Yoon Soo, Kim, Jong-Choon, Ko, Je-Won, Shin, In-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133850/
https://www.ncbi.nlm.nih.gov/pubmed/34055011
http://dx.doi.org/10.1155/2021/5585692
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author Lee, Se-Jin
Lee, A. Yeong
Lim, Je-Oh
Lee, Ji Hye
Jung, Tae-Yang
Pak, So-Won
Kim, Woong-Il
Seo, Yoon Soo
Kim, Jong-Choon
Ko, Je-Won
Shin, In-Sik
author_facet Lee, Se-Jin
Lee, A. Yeong
Lim, Je-Oh
Lee, Ji Hye
Jung, Tae-Yang
Pak, So-Won
Kim, Woong-Il
Seo, Yoon Soo
Kim, Jong-Choon
Ko, Je-Won
Shin, In-Sik
author_sort Lee, Se-Jin
collection PubMed
description Yijin-tang is an oriental traditional herb used to treat inflammatory diseases. In the present study, we investigated the protective effects of Yijin-tang water extract (YTE) using an ovalbumin- (OVA-) induced asthma model, focusing on the antioxidant and anti-inflammatory properties of the herb. BALB/c mice were intraperitoneally injected with OVA on days 0 and 14 and then challenged with OVA on days 21, 22, and 23. The animals were orally administered YTE (200 and 400 mg/kg) from days 18 to 23, and this was found to significantly decrease airway hyperresponsiveness and release of inflammatory cells, cytokines, and OVA-specific immunoglobulin E in mice with asthma. In addition, YTE was associated with a marked reduction in airway inflammation and mucus production in lung tissue of mice with asthma. Furthermore, YTE suppressed the expression of matrix metalloproteinase-9 and phosphorylation of ERK in the lungs, which in turn led to a reduction in inducible nitric oxide synthases and an elevation in reduced glutathione and heme oxygenase-1. In conclusion, YTE effectively suppressed allergic responses in mice with asthma and the effect was closely related to antioxidant and anti-inflammatory properties of the herb. Our results indicate that YTE may be a potential agent for the treatment of allergic asthma.
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spelling pubmed-81338502021-05-27 Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model Lee, Se-Jin Lee, A. Yeong Lim, Je-Oh Lee, Ji Hye Jung, Tae-Yang Pak, So-Won Kim, Woong-Il Seo, Yoon Soo Kim, Jong-Choon Ko, Je-Won Shin, In-Sik Evid Based Complement Alternat Med Research Article Yijin-tang is an oriental traditional herb used to treat inflammatory diseases. In the present study, we investigated the protective effects of Yijin-tang water extract (YTE) using an ovalbumin- (OVA-) induced asthma model, focusing on the antioxidant and anti-inflammatory properties of the herb. BALB/c mice were intraperitoneally injected with OVA on days 0 and 14 and then challenged with OVA on days 21, 22, and 23. The animals were orally administered YTE (200 and 400 mg/kg) from days 18 to 23, and this was found to significantly decrease airway hyperresponsiveness and release of inflammatory cells, cytokines, and OVA-specific immunoglobulin E in mice with asthma. In addition, YTE was associated with a marked reduction in airway inflammation and mucus production in lung tissue of mice with asthma. Furthermore, YTE suppressed the expression of matrix metalloproteinase-9 and phosphorylation of ERK in the lungs, which in turn led to a reduction in inducible nitric oxide synthases and an elevation in reduced glutathione and heme oxygenase-1. In conclusion, YTE effectively suppressed allergic responses in mice with asthma and the effect was closely related to antioxidant and anti-inflammatory properties of the herb. Our results indicate that YTE may be a potential agent for the treatment of allergic asthma. Hindawi 2021-05-11 /pmc/articles/PMC8133850/ /pubmed/34055011 http://dx.doi.org/10.1155/2021/5585692 Text en Copyright © 2021 Se-Jin Lee et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lee, Se-Jin
Lee, A. Yeong
Lim, Je-Oh
Lee, Ji Hye
Jung, Tae-Yang
Pak, So-Won
Kim, Woong-Il
Seo, Yoon Soo
Kim, Jong-Choon
Ko, Je-Won
Shin, In-Sik
Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model
title Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model
title_full Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model
title_fullStr Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model
title_full_unstemmed Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model
title_short Effect of Yijin-Tang, an Oriental Traditional Formula, on Allergic Responses Using an Ovalbumin-Induced Murine Asthma Model
title_sort effect of yijin-tang, an oriental traditional formula, on allergic responses using an ovalbumin-induced murine asthma model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133850/
https://www.ncbi.nlm.nih.gov/pubmed/34055011
http://dx.doi.org/10.1155/2021/5585692
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