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Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target

Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary tract. The carcinogenesis of CCA is associated with genomic and epigenetic abnormalities, as well as environmental effects. However, early clinical diagnosis and reliable treatment strategies of CCA remain unsatis...

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Autores principales: Zhou, Menghua, Wang, Chaoqun, Lu, Shounan, Xu, Yanan, Li, Zihao, Jiang, Hongchi, Ma, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134032/
https://www.ncbi.nlm.nih.gov/pubmed/33993051
http://dx.doi.org/10.1016/j.ebiom.2021.103375
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author Zhou, Menghua
Wang, Chaoqun
Lu, Shounan
Xu, Yanan
Li, Zihao
Jiang, Hongchi
Ma, Yong
author_facet Zhou, Menghua
Wang, Chaoqun
Lu, Shounan
Xu, Yanan
Li, Zihao
Jiang, Hongchi
Ma, Yong
author_sort Zhou, Menghua
collection PubMed
description Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary tract. The carcinogenesis of CCA is associated with genomic and epigenetic abnormalities, as well as environmental effects. However, early clinical diagnosis and reliable treatment strategies of CCA remain unsatisfactory. Multiple compartments of the tumor microenvironment significantly affect the progression of CCA. Tumor-associated macrophages (TAMs) are a type of plastic immune cells that are recruited and activated in the CCA microenvironment, especially at the tumor invasive front and perivascular sites. TAMs create a favorable environment that benefits CCA growth by closely interacting with CCA cells and other stromal cells via releasing multiple protumor factors. In addition, TAMs exert immunosuppressive and antichemotherapeutic effects, thus intensifying the malignancy. Targeting TAMs may provide an improved understanding of, and novel therapeutic approaches for, CCA. This review focuses on revealing the interplay between TAMs and CCA.
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spelling pubmed-81340322021-05-21 Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target Zhou, Menghua Wang, Chaoqun Lu, Shounan Xu, Yanan Li, Zihao Jiang, Hongchi Ma, Yong EBioMedicine Review Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary tract. The carcinogenesis of CCA is associated with genomic and epigenetic abnormalities, as well as environmental effects. However, early clinical diagnosis and reliable treatment strategies of CCA remain unsatisfactory. Multiple compartments of the tumor microenvironment significantly affect the progression of CCA. Tumor-associated macrophages (TAMs) are a type of plastic immune cells that are recruited and activated in the CCA microenvironment, especially at the tumor invasive front and perivascular sites. TAMs create a favorable environment that benefits CCA growth by closely interacting with CCA cells and other stromal cells via releasing multiple protumor factors. In addition, TAMs exert immunosuppressive and antichemotherapeutic effects, thus intensifying the malignancy. Targeting TAMs may provide an improved understanding of, and novel therapeutic approaches for, CCA. This review focuses on revealing the interplay between TAMs and CCA. Elsevier 2021-05-13 /pmc/articles/PMC8134032/ /pubmed/33993051 http://dx.doi.org/10.1016/j.ebiom.2021.103375 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhou, Menghua
Wang, Chaoqun
Lu, Shounan
Xu, Yanan
Li, Zihao
Jiang, Hongchi
Ma, Yong
Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target
title Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target
title_full Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target
title_fullStr Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target
title_full_unstemmed Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target
title_short Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target
title_sort tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134032/
https://www.ncbi.nlm.nih.gov/pubmed/33993051
http://dx.doi.org/10.1016/j.ebiom.2021.103375
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