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Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana
OBJECTIVE: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases w...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134059/ https://www.ncbi.nlm.nih.gov/pubmed/33667696 http://dx.doi.org/10.1016/j.ijid.2021.02.110 |
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author | Asare, Prince Osei-Wusu, Stephen Baddoo, Nyonuku Akosua Bedeley, Edmund Otchere, Isaac Darko Brites, Daniela Loiseau, Chloé Asante-Poku, Adwoa Prah, Diana Ahu Borrell, Sonia Reinhard, Miriam Omari, Michael Amo Forson, Audrey Koram, Kwadwo Ansah Gagneux, Sebastien Yeboah-Manu, Dorothy |
author_facet | Asare, Prince Osei-Wusu, Stephen Baddoo, Nyonuku Akosua Bedeley, Edmund Otchere, Isaac Darko Brites, Daniela Loiseau, Chloé Asante-Poku, Adwoa Prah, Diana Ahu Borrell, Sonia Reinhard, Miriam Omari, Michael Amo Forson, Audrey Koram, Kwadwo Ansah Gagneux, Sebastien Yeboah-Manu, Dorothy |
author_sort | Asare, Prince |
collection | PubMed |
description | OBJECTIVE: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases were characterized by standard mycobacterial genotyping tools, whole-genome sequencing, and phylogenetic analysis carried out to assess strain relatedness. RESULTS: The majority (58.3%, 21/36) of study participants with rcTB episodes had TB recurrence within 12 months post treatment. TB strains with isoniazid (INH) resistance were found in 19.4% (7/36) of participants at the primary episode, of which 29% (2/7) were also rifampicin-resistant. On TB recurrence, an INH-resistant strain was found in a larger proportion of participants, 27.8% (10/36), of which 40% (4/10) were MDR-TB strains. rcTB was attributed to relapse (same strain) in 75.0% (27/36) of participants and 25.0% (9/36) to re-infection. CONCLUSION: Our findings indicate that previous unresolved infectiondue to inadequate treatment, may be the major cause of rcTB. |
format | Online Article Text |
id | pubmed-8134059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81340592021-05-24 Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana Asare, Prince Osei-Wusu, Stephen Baddoo, Nyonuku Akosua Bedeley, Edmund Otchere, Isaac Darko Brites, Daniela Loiseau, Chloé Asante-Poku, Adwoa Prah, Diana Ahu Borrell, Sonia Reinhard, Miriam Omari, Michael Amo Forson, Audrey Koram, Kwadwo Ansah Gagneux, Sebastien Yeboah-Manu, Dorothy Int J Infect Dis Article OBJECTIVE: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases were characterized by standard mycobacterial genotyping tools, whole-genome sequencing, and phylogenetic analysis carried out to assess strain relatedness. RESULTS: The majority (58.3%, 21/36) of study participants with rcTB episodes had TB recurrence within 12 months post treatment. TB strains with isoniazid (INH) resistance were found in 19.4% (7/36) of participants at the primary episode, of which 29% (2/7) were also rifampicin-resistant. On TB recurrence, an INH-resistant strain was found in a larger proportion of participants, 27.8% (10/36), of which 40% (4/10) were MDR-TB strains. rcTB was attributed to relapse (same strain) in 75.0% (27/36) of participants and 25.0% (9/36) to re-infection. CONCLUSION: Our findings indicate that previous unresolved infectiondue to inadequate treatment, may be the major cause of rcTB. Elsevier 2021-05 /pmc/articles/PMC8134059/ /pubmed/33667696 http://dx.doi.org/10.1016/j.ijid.2021.02.110 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Asare, Prince Osei-Wusu, Stephen Baddoo, Nyonuku Akosua Bedeley, Edmund Otchere, Isaac Darko Brites, Daniela Loiseau, Chloé Asante-Poku, Adwoa Prah, Diana Ahu Borrell, Sonia Reinhard, Miriam Omari, Michael Amo Forson, Audrey Koram, Kwadwo Ansah Gagneux, Sebastien Yeboah-Manu, Dorothy Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana |
title | Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana |
title_full | Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana |
title_fullStr | Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana |
title_full_unstemmed | Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana |
title_short | Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana |
title_sort | genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in ghana |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134059/ https://www.ncbi.nlm.nih.gov/pubmed/33667696 http://dx.doi.org/10.1016/j.ijid.2021.02.110 |
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