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Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana

OBJECTIVE: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases w...

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Autores principales: Asare, Prince, Osei-Wusu, Stephen, Baddoo, Nyonuku Akosua, Bedeley, Edmund, Otchere, Isaac Darko, Brites, Daniela, Loiseau, Chloé, Asante-Poku, Adwoa, Prah, Diana Ahu, Borrell, Sonia, Reinhard, Miriam, Omari, Michael Amo, Forson, Audrey, Koram, Kwadwo Ansah, Gagneux, Sebastien, Yeboah-Manu, Dorothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134059/
https://www.ncbi.nlm.nih.gov/pubmed/33667696
http://dx.doi.org/10.1016/j.ijid.2021.02.110
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author Asare, Prince
Osei-Wusu, Stephen
Baddoo, Nyonuku Akosua
Bedeley, Edmund
Otchere, Isaac Darko
Brites, Daniela
Loiseau, Chloé
Asante-Poku, Adwoa
Prah, Diana Ahu
Borrell, Sonia
Reinhard, Miriam
Omari, Michael Amo
Forson, Audrey
Koram, Kwadwo Ansah
Gagneux, Sebastien
Yeboah-Manu, Dorothy
author_facet Asare, Prince
Osei-Wusu, Stephen
Baddoo, Nyonuku Akosua
Bedeley, Edmund
Otchere, Isaac Darko
Brites, Daniela
Loiseau, Chloé
Asante-Poku, Adwoa
Prah, Diana Ahu
Borrell, Sonia
Reinhard, Miriam
Omari, Michael Amo
Forson, Audrey
Koram, Kwadwo Ansah
Gagneux, Sebastien
Yeboah-Manu, Dorothy
author_sort Asare, Prince
collection PubMed
description OBJECTIVE: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases were characterized by standard mycobacterial genotyping tools, whole-genome sequencing, and phylogenetic analysis carried out to assess strain relatedness. RESULTS: The majority (58.3%, 21/36) of study participants with rcTB episodes had TB recurrence within 12 months post treatment. TB strains with isoniazid (INH) resistance were found in 19.4% (7/36) of participants at the primary episode, of which 29% (2/7) were also rifampicin-resistant. On TB recurrence, an INH-resistant strain was found in a larger proportion of participants, 27.8% (10/36), of which 40% (4/10) were MDR-TB strains. rcTB was attributed to relapse (same strain) in 75.0% (27/36) of participants and 25.0% (9/36) to re-infection. CONCLUSION: Our findings indicate that previous unresolved infectiondue to inadequate treatment, may be the major cause of rcTB.
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spelling pubmed-81340592021-05-24 Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana Asare, Prince Osei-Wusu, Stephen Baddoo, Nyonuku Akosua Bedeley, Edmund Otchere, Isaac Darko Brites, Daniela Loiseau, Chloé Asante-Poku, Adwoa Prah, Diana Ahu Borrell, Sonia Reinhard, Miriam Omari, Michael Amo Forson, Audrey Koram, Kwadwo Ansah Gagneux, Sebastien Yeboah-Manu, Dorothy Int J Infect Dis Article OBJECTIVE: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases were characterized by standard mycobacterial genotyping tools, whole-genome sequencing, and phylogenetic analysis carried out to assess strain relatedness. RESULTS: The majority (58.3%, 21/36) of study participants with rcTB episodes had TB recurrence within 12 months post treatment. TB strains with isoniazid (INH) resistance were found in 19.4% (7/36) of participants at the primary episode, of which 29% (2/7) were also rifampicin-resistant. On TB recurrence, an INH-resistant strain was found in a larger proportion of participants, 27.8% (10/36), of which 40% (4/10) were MDR-TB strains. rcTB was attributed to relapse (same strain) in 75.0% (27/36) of participants and 25.0% (9/36) to re-infection. CONCLUSION: Our findings indicate that previous unresolved infectiondue to inadequate treatment, may be the major cause of rcTB. Elsevier 2021-05 /pmc/articles/PMC8134059/ /pubmed/33667696 http://dx.doi.org/10.1016/j.ijid.2021.02.110 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Asare, Prince
Osei-Wusu, Stephen
Baddoo, Nyonuku Akosua
Bedeley, Edmund
Otchere, Isaac Darko
Brites, Daniela
Loiseau, Chloé
Asante-Poku, Adwoa
Prah, Diana Ahu
Borrell, Sonia
Reinhard, Miriam
Omari, Michael Amo
Forson, Audrey
Koram, Kwadwo Ansah
Gagneux, Sebastien
Yeboah-Manu, Dorothy
Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana
title Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana
title_full Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana
title_fullStr Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana
title_full_unstemmed Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana
title_short Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana
title_sort genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in ghana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134059/
https://www.ncbi.nlm.nih.gov/pubmed/33667696
http://dx.doi.org/10.1016/j.ijid.2021.02.110
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