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PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding

Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders characterized by the deposition of hyperphosphorylated tau aggregates. Proteopathic tau seeds spread through the brain in a temporospatial pattern, indicative of transsynaptic propagation. It is hypothesized that red...

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Detalles Bibliográficos
Autores principales:	Soares, Alberto Carpinteiro, Ferreira, Andreia, Mariën, Jonas, Delay, Charlotte, Lee, Edward, Trojanowski, John Q., Moechars, Dieder, Annaert, Wim, De Muynck, Louis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134070/ https://www.ncbi.nlm.nih.gov/pubmed/33831417 http://dx.doi.org/10.1016/j.jbc.2021.100636

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