Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria. Reports from the toxicological literature suggest...

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Detalles Bibliográficos
Autores principales: Hershberger, Kathleen A., Rooney, John P., Turner, Elena A., Donoghue, Lauren J., Bodhicharla, Rakesh, Maurer, Laura L., Ryde, Ian T., Kim, Jina J., Joglekar, Rashmi, Hibshman, Jonathan D., Smith, Latasha L., Bhatt, Dhaval P., Ilkayeva, Olga R., Hirschey, Matthew D., Meyer, Joel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134077/
https://www.ncbi.nlm.nih.gov/pubmed/33993056
http://dx.doi.org/10.1016/j.redox.2021.102000

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