Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes

Type 2 diabetes is characterized by β and α cell dysfunction. We used phasor-FLIM (Fluorescence Lifetime Imaging Microscopy) to monitor oxidative phosphorylation and glycolysis in living islet cells before and after glucose stimulation. In healthy cells, glucose enhanced oxidative phosphorylation in...

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Detalles Bibliográficos
Autores principales: Wang, Zhongying, Gurlo, Tatyana, Matveyenko, Aleksey V., Elashoff, David, Wang, Peiyu, Rosenberger, Madeline, Junge, Jason A., Stevens, Raymond C., White, Kate L., Fraser, Scott E., Butler, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134470/
https://www.ncbi.nlm.nih.gov/pubmed/34012065
http://dx.doi.org/10.1038/s42003-021-02113-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134470/
https://www.ncbi.nlm.nih.gov/pubmed/34012065
http://dx.doi.org/10.1038/s42003-021-02113-1

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