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Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes

Type 2 diabetes is characterized by β and α cell dysfunction. We used phasor-FLIM (Fluorescence Lifetime Imaging Microscopy) to monitor oxidative phosphorylation and glycolysis in living islet cells before and after glucose stimulation. In healthy cells, glucose enhanced oxidative phosphorylation in...

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Detalles Bibliográficos
Autores principales:	Wang, Zhongying, Gurlo, Tatyana, Matveyenko, Aleksey V., Elashoff, David, Wang, Peiyu, Rosenberger, Madeline, Junge, Jason A., Stevens, Raymond C., White, Kate L., Fraser, Scott E., Butler, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134470/ https://www.ncbi.nlm.nih.gov/pubmed/34012065 http://dx.doi.org/10.1038/s42003-021-02113-1

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