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Club cell-specific role of programmed cell death 5 in pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibr...

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Autores principales: Park, Soo-Yeon, Hong, Jung Yeon, Lee, Soo Yeon, Lee, Seung-Hyun, Kim, Mi Jeong, Kim, Soo Yeon, Kim, Kyung Won, Shim, Hyo Sup, Park, Moo Suk, Lee, Chun Geun, Elias, Jack A., Sohn, Myung Hyun, Yoon, Ho-Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134485/
https://www.ncbi.nlm.nih.gov/pubmed/34011956
http://dx.doi.org/10.1038/s41467-021-23277-8
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author Park, Soo-Yeon
Hong, Jung Yeon
Lee, Soo Yeon
Lee, Seung-Hyun
Kim, Mi Jeong
Kim, Soo Yeon
Kim, Kyung Won
Shim, Hyo Sup
Park, Moo Suk
Lee, Chun Geun
Elias, Jack A.
Sohn, Myung Hyun
Yoon, Ho-Geun
author_facet Park, Soo-Yeon
Hong, Jung Yeon
Lee, Soo Yeon
Lee, Seung-Hyun
Kim, Mi Jeong
Kim, Soo Yeon
Kim, Kyung Won
Shim, Hyo Sup
Park, Moo Suk
Lee, Chun Geun
Elias, Jack A.
Sohn, Myung Hyun
Yoon, Ho-Geun
author_sort Park, Soo-Yeon
collection PubMed
description Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular genes. Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast proliferation and collagen synthesis. Here, we demonstrate the club cell-specific role of PDCD5 as a mediator of lung fibrosis and potential therapeutic target for IPF.
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spelling pubmed-81344852021-05-24 Club cell-specific role of programmed cell death 5 in pulmonary fibrosis Park, Soo-Yeon Hong, Jung Yeon Lee, Soo Yeon Lee, Seung-Hyun Kim, Mi Jeong Kim, Soo Yeon Kim, Kyung Won Shim, Hyo Sup Park, Moo Suk Lee, Chun Geun Elias, Jack A. Sohn, Myung Hyun Yoon, Ho-Geun Nat Commun Article Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular genes. Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast proliferation and collagen synthesis. Here, we demonstrate the club cell-specific role of PDCD5 as a mediator of lung fibrosis and potential therapeutic target for IPF. Nature Publishing Group UK 2021-05-19 /pmc/articles/PMC8134485/ /pubmed/34011956 http://dx.doi.org/10.1038/s41467-021-23277-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Park, Soo-Yeon
Hong, Jung Yeon
Lee, Soo Yeon
Lee, Seung-Hyun
Kim, Mi Jeong
Kim, Soo Yeon
Kim, Kyung Won
Shim, Hyo Sup
Park, Moo Suk
Lee, Chun Geun
Elias, Jack A.
Sohn, Myung Hyun
Yoon, Ho-Geun
Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
title Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
title_full Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
title_fullStr Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
title_full_unstemmed Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
title_short Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
title_sort club cell-specific role of programmed cell death 5 in pulmonary fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134485/
https://www.ncbi.nlm.nih.gov/pubmed/34011956
http://dx.doi.org/10.1038/s41467-021-23277-8
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