Decreased vascular smooth muscle contractility in Hutchinson–Gilford Progeria Syndrome linked to defective smooth muscle myosin heavy chain expression

Children with Hutchinson–Gilford Progeria Syndrome (HGPS) suffer from multiple cardiovascular pathologies due to the expression of progerin, a mutant form of the nuclear envelope protein Lamin A. Progerin expression has a dramatic effect on arterial smooth muscle cells (SMCs) and results in decrease...

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Detalles Bibliográficos
Autores principales: von Kleeck, Ryan, Castagnino, Paola, Roberts, Emilia, Talwar, Shefali, Ferrari, Giovanni, Assoian, Richard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134495/
https://www.ncbi.nlm.nih.gov/pubmed/34012019
http://dx.doi.org/10.1038/s41598-021-90119-4

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