CD28 engagement inhibits CD73-mediated regulatory activity of CD8(+) T cells

CD28 is required for T cell activation as well as the generation of CD4(+)Foxp3(+) Treg. It is unclear, however, how CD28 costimulation affects the development of CD8(+) T cell suppressive function. Here, by use of Hepa1.6.gp33 in vitro killing assay and B16.gp33 tumor mouse model we demonstrate tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Yo-Ping, Kuo, Lu-Cheng, Lin, Been-Ren, Lin, Hung-Ju, Lin, Chih-Yu, Chen, Yi-Ting, Hsiao, Pei-Wen, Chang, Huan-Tsung, Ko, Patrick Chow-In, Chen, Hsiao-Chin, Chang, Hsiang-Yu, Lu, Jean, Ho, Hong-Nerng, Wu-Hsieh, Betty A., Kung, John T., Chen, Shu-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134507/
https://www.ncbi.nlm.nih.gov/pubmed/34011962
http://dx.doi.org/10.1038/s42003-021-02119-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134507/
https://www.ncbi.nlm.nih.gov/pubmed/34011962
http://dx.doi.org/10.1038/s42003-021-02119-9

Ejemplares similares