Cargando…

CD28 engagement inhibits CD73-mediated regulatory activity of CD8(+) T cells

CD28 is required for T cell activation as well as the generation of CD4(+)Foxp3(+) Treg. It is unclear, however, how CD28 costimulation affects the development of CD8(+) T cell suppressive function. Here, by use of Hepa1.6.gp33 in vitro killing assay and B16.gp33 tumor mouse model we demonstrate tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lai, Yo-Ping, Kuo, Lu-Cheng, Lin, Been-Ren, Lin, Hung-Ju, Lin, Chih-Yu, Chen, Yi-Ting, Hsiao, Pei-Wen, Chang, Huan-Tsung, Ko, Patrick Chow-In, Chen, Hsiao-Chin, Chang, Hsiang-Yu, Lu, Jean, Ho, Hong-Nerng, Wu-Hsieh, Betty A., Kung, John T., Chen, Shu-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134507/ https://www.ncbi.nlm.nih.gov/pubmed/34011962 http://dx.doi.org/10.1038/s42003-021-02119-9

Ejemplares similares

Monitoring and characterizing soluble and membrane-bound ectonucleotidases CD73 and CD39
por: Goueli, Said A., et al.
Publicado: (2019)

Defects in the Acquisition of Tumor-Killing Capability of CD8(+) Cytotoxic T Cells in Streptozotocin-Induced Diabetic Mice
por: Chen, Shu-Ching, et al.
Publicado: (2014)

CD73 is associated with poor prognosis in HNSCC
por: Ren, Zhen-Hu, et al.
Publicado: (2016)

The Roles of CD73 in Cancer
por: Gao, Zhao-wei, et al.
Publicado: (2014)

Decreased CD8(+)CD28(+)/CD8(+)CD28(–) T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease
por: Dai, Shi-xue, et al.
Publicado: (2017)

CD28(−) and CD28(low)CD8(+) Regulatory T Cells: Of Mice and Men
por: Vuddamalay, Yirajen, et al.
Publicado: (2017)

CD73 promotes colitis-associated tumorigenesis in mice
por: Liu, Xuan-Hui, et al.
Publicado: (2020)

The distinct role of CD73 in the progression of pancreatic cancer
por: Zhou, Liangjing, et al.
Publicado: (2019)

Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets
por: Chen, Tso-Hsiao, et al.
Publicado: (2015)

The Concordant Disruption of B7/CD28 Immune Regulators Predicts the Prognosis of Oral Carcinomas
por: Chang, Shi-Rou, et al.
Publicado: (2023)

Expression and correlation of CD44 and GP73 in cerebroma tissues
por: Yuan, Yuan, et al.
Publicado: (2018)

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73(-) Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes
por: Ahmadi, Parimah, et al.
Publicado: (2020)

Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus
por: Lin, Syh-Jae, et al.
Publicado: (2016)

The Clinical Significance of CD73 in Cancer
por: Bach, Niklas, et al.
Publicado: (2023)

CD73, a significant protein in liver diseases
por: Shi, Huilian, et al.
Publicado: (2023)

Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR
por: Ploeg, Emily Maria, et al.
Publicado: (2023)

CD73-Positive Cell Spheroid Transplantation Attenuates Colonic Atrophy
por: Hisamatsu, Daisuke, et al.
Publicado: (2023)

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians
por: Crooke, Almudena, et al.
Publicado: (2017)

CD39 and CD73 as Promising Therapeutic Targets: What Could Be the Limitations?
por: Battastini, Ana Maria Oliveira, et al.
Publicado: (2021)

Ecto-5′-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells
por: Rosemblatt, Mariana V., et al.
Publicado: (2021)

CD39/CD73/A2AR pathway and cancer immunotherapy
por: Xia, Chenglai, et al.
Publicado: (2023)

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy
por: Jiang, Xuan, et al.
Publicado: (2023)

Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer
por: Gardani, Carla Fernanda Furtado, et al.
Publicado: (2023)

CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73
Publicado: (1995)

CD73 Promotes Tumor Progression in Patients with Esophageal Squamous Cell Carcinoma
por: Chen, Yen-Hao, et al.
Publicado: (2021)

CD39/CD73 Dysregulation of Adenosine Metabolism Increases Decidual Natural Killer Cell Cytotoxicity: Implications in Unexplained Recurrent Spontaneous Abortion
por: Zhu, Jianan, et al.
Publicado: (2022)

CD3(+)CD8(+)CD28(−) T Lymphocytes in Patients with Lupus Nephritis
por: Żabińska, Marcelina, et al.
Publicado: (2016)

Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86–Positive B Cell Malignancies
por: Lin, Shouheng, et al.
Publicado: (2021)

CD73 Promotes Chronic Lymphocytic Leukemia
por: Allard, David, et al.
Publicado: (2022)

CD73: Friend or Foe in Lung Injury
por: Hu, Xiu-Min, et al.
Publicado: (2023)

CD73 Dysregulates Monocyte Anti-Tumor Activity in Multiple Myeloma
por: Zhou, Lin, et al.
Publicado: (2023)

Prognostic significance of peripheral CD8+CD28+ and CD8+CD28− T cells in advanced non-small cell lung cancer patients treated with chemo(radio)therapy
por: Liu, Chao, et al.
Publicado: (2019)

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
por: Muller, Yannick D., et al.
Publicado: (2021)

NSOM/QD-Based Direct Visualization of CD3-Induced and CD28-Enhanced Nanospatial Coclustering of TCR and Coreceptor in Nanodomains in T Cell Activation
por: Zhong, Liyun, et al.
Publicado: (2009)

High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors
por: Aliagas, Elisabet, et al.
Publicado: (2014)

The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation
por: Roberts, Veena, et al.
Publicado: (2014)

Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors
por: Lee, Po-Hsin, et al.
Publicado: (2021)

Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
por: Fu, Ziyi, et al.
Publicado: (2023)

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
por: Deaglio, Silvia, et al.
Publicado: (2007)

CD73, CD90, CD105 and Cadherin-11 RT-PCR Screening for Mesenchymal Stem Cells from Cryopreserved Human Cord Tissue
por: Pham, Hung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6tc0r7ahu9n5glp1opf3rm686q