Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover

The association between reduced myofilament force-generating capacity (F(max)) and heart failure (HF) is clear, however the underlying molecular mechanisms are poorly understood. Here, we show impaired F(max) arises from reduced BAG3-mediated sarcomere turnover. Myofilament BAG3 expression decreases...

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Detalles Bibliográficos
Autores principales: Martin, Thomas G., Myers, Valerie D., Dubey, Praveen, Dubey, Shubham, Perez, Edith, Moravec, Christine S., Willis, Monte S., Feldman, Arthur M., Kirk, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134551/
https://www.ncbi.nlm.nih.gov/pubmed/34011988
http://dx.doi.org/10.1038/s41467-021-23272-z

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