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Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis

Emerging evidence suggest association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the development of many liver abnormalities. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on the profiles of...

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Autores principales: Bzeizi, Khalid, Abdulla, Maheeba, Mohammed, Nafeesa, Alqamish, Jehad, Jamshidi, Negar, Broering, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134580/
https://www.ncbi.nlm.nih.gov/pubmed/34012016
http://dx.doi.org/10.1038/s41598-021-89513-9
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author Bzeizi, Khalid
Abdulla, Maheeba
Mohammed, Nafeesa
Alqamish, Jehad
Jamshidi, Negar
Broering, Dieter
author_facet Bzeizi, Khalid
Abdulla, Maheeba
Mohammed, Nafeesa
Alqamish, Jehad
Jamshidi, Negar
Broering, Dieter
author_sort Bzeizi, Khalid
collection PubMed
description Emerging evidence suggest association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the development of many liver abnormalities. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on the profiles of liver chemistries and coagulation in COVID-19 diagnosed patients. We considered all study designs including epidemiological and observational that reported liver function test abnormalities in patients confirmed with SARS-CoV-2 infection. Medline, Embase databases and Google Scholar as well as relevant reviews were searched to identify appropriate studies from inception to 31st of August 2020. We calculated the pooled mean with 95% confidence intervals (95% CI) through a random-effect model meta-analysis. A total of 35 studies with 10,692 participants were considered for the review from which 23 studies with sufficient quantitative data were included in the meta-analysis. The pooled mean for liver enzymes and coagulation parameters did not significantly change in patients diagnosed with COVID-19 and remained within normal range. Notwithstanding potential bias from confounding factors in interpretation of data in this review, findings from the observational studies and case reports suggest that COVID-19 does not appear to have a significant impact on the transaminases or total bilirubin levels of patients with confirmed SARS-CoV-2 infection. Further controlled studies and larger sample size observational studies are needed with adequate reporting of other liver function parameters are warranted.
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spelling pubmed-81345802021-05-25 Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis Bzeizi, Khalid Abdulla, Maheeba Mohammed, Nafeesa Alqamish, Jehad Jamshidi, Negar Broering, Dieter Sci Rep Article Emerging evidence suggest association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the development of many liver abnormalities. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on the profiles of liver chemistries and coagulation in COVID-19 diagnosed patients. We considered all study designs including epidemiological and observational that reported liver function test abnormalities in patients confirmed with SARS-CoV-2 infection. Medline, Embase databases and Google Scholar as well as relevant reviews were searched to identify appropriate studies from inception to 31st of August 2020. We calculated the pooled mean with 95% confidence intervals (95% CI) through a random-effect model meta-analysis. A total of 35 studies with 10,692 participants were considered for the review from which 23 studies with sufficient quantitative data were included in the meta-analysis. The pooled mean for liver enzymes and coagulation parameters did not significantly change in patients diagnosed with COVID-19 and remained within normal range. Notwithstanding potential bias from confounding factors in interpretation of data in this review, findings from the observational studies and case reports suggest that COVID-19 does not appear to have a significant impact on the transaminases or total bilirubin levels of patients with confirmed SARS-CoV-2 infection. Further controlled studies and larger sample size observational studies are needed with adequate reporting of other liver function parameters are warranted. Nature Publishing Group UK 2021-05-19 /pmc/articles/PMC8134580/ /pubmed/34012016 http://dx.doi.org/10.1038/s41598-021-89513-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bzeizi, Khalid
Abdulla, Maheeba
Mohammed, Nafeesa
Alqamish, Jehad
Jamshidi, Negar
Broering, Dieter
Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_full Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_fullStr Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_full_unstemmed Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_short Effect of COVID-19 on liver abnormalities: a systematic review and meta‐analysis
title_sort effect of covid-19 on liver abnormalities: a systematic review and meta‐analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134580/
https://www.ncbi.nlm.nih.gov/pubmed/34012016
http://dx.doi.org/10.1038/s41598-021-89513-9
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