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Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review
Posterior reversible encephalopathy syndrome (PRES) is a relatively rare clinical disease, characterized by reversible subcortical vasogenic edema. Here, we present the first reported case of PRES induced by anlotinib, a multi-target tyrosine kinase inhibitor. A 56-year-old female patient with lung...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134686/ https://www.ncbi.nlm.nih.gov/pubmed/34025545 http://dx.doi.org/10.3389/fneur.2021.546481 |
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author | Nan, Di Yin, Xiang Ma, Di Jiang, Xiaoyu Wu, Baihua Feng, Jiachun |
author_facet | Nan, Di Yin, Xiang Ma, Di Jiang, Xiaoyu Wu, Baihua Feng, Jiachun |
author_sort | Nan, Di |
collection | PubMed |
description | Posterior reversible encephalopathy syndrome (PRES) is a relatively rare clinical disease, characterized by reversible subcortical vasogenic edema. Here, we present the first reported case of PRES induced by anlotinib, a multi-target tyrosine kinase inhibitor. A 56-year-old female patient with lung adenocarcinoma and bone metastasis experienced hypertension and mental confusion when she received anti-angiogenesis treatment. PRES was diagnosed after magnetic resonance of the patient's brain revealed hyperintensities bilaterally around the cerebellum, pons, fronto-parieto-occipital areas, and corona radiate. Diffusion-weighted imaging showed hyperintensities bilaterally in the parieto-occipital cortical regions. Subsequently, the patient was diagnosed with PRES, and remission was achieved with anti-hypertensive drugs. Six cases of rare adverse effects induced by anlotinib were reviewed in the literature. Since anlotinib has been widely applied as a novel third-line treatment in patients with non-small-cell lung cancer, the association between PRES and anlotinib would benefit neurologists and oncologists in future diagnoses and treatment. |
format | Online Article Text |
id | pubmed-8134686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81346862021-05-21 Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review Nan, Di Yin, Xiang Ma, Di Jiang, Xiaoyu Wu, Baihua Feng, Jiachun Front Neurol Neurology Posterior reversible encephalopathy syndrome (PRES) is a relatively rare clinical disease, characterized by reversible subcortical vasogenic edema. Here, we present the first reported case of PRES induced by anlotinib, a multi-target tyrosine kinase inhibitor. A 56-year-old female patient with lung adenocarcinoma and bone metastasis experienced hypertension and mental confusion when she received anti-angiogenesis treatment. PRES was diagnosed after magnetic resonance of the patient's brain revealed hyperintensities bilaterally around the cerebellum, pons, fronto-parieto-occipital areas, and corona radiate. Diffusion-weighted imaging showed hyperintensities bilaterally in the parieto-occipital cortical regions. Subsequently, the patient was diagnosed with PRES, and remission was achieved with anti-hypertensive drugs. Six cases of rare adverse effects induced by anlotinib were reviewed in the literature. Since anlotinib has been widely applied as a novel third-line treatment in patients with non-small-cell lung cancer, the association between PRES and anlotinib would benefit neurologists and oncologists in future diagnoses and treatment. Frontiers Media S.A. 2021-05-06 /pmc/articles/PMC8134686/ /pubmed/34025545 http://dx.doi.org/10.3389/fneur.2021.546481 Text en Copyright © 2021 Nan, Yin, Ma, Jiang, Wu and Feng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Nan, Di Yin, Xiang Ma, Di Jiang, Xiaoyu Wu, Baihua Feng, Jiachun Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review |
title | Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review |
title_full | Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review |
title_fullStr | Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review |
title_full_unstemmed | Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review |
title_short | Posterior Reversible Encephalopathy Syndrome Associated With Anlotinib: A Case Report and Literature Review |
title_sort | posterior reversible encephalopathy syndrome associated with anlotinib: a case report and literature review |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134686/ https://www.ncbi.nlm.nih.gov/pubmed/34025545 http://dx.doi.org/10.3389/fneur.2021.546481 |
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