High BRAF variant allele frequencies are associated with distinct pathological features and responsiveness to target therapy in melanoma patients

BACKGROUND: BRAF mutant melanoma patients are commonly treated with anti-BRAF therapeutic strategies. However, many factors, including the percentage of BRAF-mutated cells, may contribute to the great variability in patient outcomes. PATIENTS AND METHODS: The BRAF variant allele frequency (VAF; defi...

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Detalles Bibliográficos
Autores principales: Berrino, E., Balsamo, A., Pisacane, A., Gallo, S., Becco, P., Miglio, U., Caravelli, D., Poletto, S., Paruzzo, L., Debernardi, C., Piccinelli, C., Zaccagna, A., Rescigno, P., Aglietta, M., Sapino, A., Carnevale-Schianca, F., Venesio, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134716/
https://www.ncbi.nlm.nih.gov/pubmed/33984673
http://dx.doi.org/10.1016/j.esmoop.2021.100133

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