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Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue
Soft tissue remodeling is a sophisticated process that sequentially provides dynamic biological signals to guide cell behavior. However, capturing these signals within hydrogel and directing over time has still been unrealized owing to the poor comprehension of physiological processes. Here, a bio-m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134719/ https://www.ncbi.nlm.nih.gov/pubmed/34027237 http://dx.doi.org/10.1016/j.bioactmat.2021.04.039 |
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author | Cai, Zhengwei Saiding, Qimanguli Cheng, Liang Zhang, Liucheng Wang, Zhen Wang, Fei Chen, Xinliang Chen, Gang Deng, Lianfu Cui, Wenguo |
author_facet | Cai, Zhengwei Saiding, Qimanguli Cheng, Liang Zhang, Liucheng Wang, Zhen Wang, Fei Chen, Xinliang Chen, Gang Deng, Lianfu Cui, Wenguo |
author_sort | Cai, Zhengwei |
collection | PubMed |
description | Soft tissue remodeling is a sophisticated process that sequentially provides dynamic biological signals to guide cell behavior. However, capturing these signals within hydrogel and directing over time has still been unrealized owing to the poor comprehension of physiological processes. Here, a bio-mimicking hydrogel is designed via thiol-ene click reaction to capture the early physical signal triggered by inflammation, and the chemical signals provided with chemokine and natural adhesion sites, which guaranteed the precise soft tissue remodeling. This bio-mimicking hydrogel efficiently facilitated cell anchoring, migration, and invasion in the 3D matrix due to the permissive space and the interaction with integrin receptors. Besides, the covalently grafted chemokine-like peptide is optimal for colonization and functional differentiation of endothelial cells through a HIF-1α dependent signal pathway. Furthermore, the early polarization of macrophages, collagen deposition and angiogenesis in rat acute wound model, and the increased blood perfusion in mouse skin flap model have confirmed that the bio-mimicking hydrogel realized precise soft tissue remodeling and opens new avenues for the phased repair of different tissues such as nerve, myocardium, and even bone. |
format | Online Article Text |
id | pubmed-8134719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-81347192021-05-21 Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue Cai, Zhengwei Saiding, Qimanguli Cheng, Liang Zhang, Liucheng Wang, Zhen Wang, Fei Chen, Xinliang Chen, Gang Deng, Lianfu Cui, Wenguo Bioact Mater Article Soft tissue remodeling is a sophisticated process that sequentially provides dynamic biological signals to guide cell behavior. However, capturing these signals within hydrogel and directing over time has still been unrealized owing to the poor comprehension of physiological processes. Here, a bio-mimicking hydrogel is designed via thiol-ene click reaction to capture the early physical signal triggered by inflammation, and the chemical signals provided with chemokine and natural adhesion sites, which guaranteed the precise soft tissue remodeling. This bio-mimicking hydrogel efficiently facilitated cell anchoring, migration, and invasion in the 3D matrix due to the permissive space and the interaction with integrin receptors. Besides, the covalently grafted chemokine-like peptide is optimal for colonization and functional differentiation of endothelial cells through a HIF-1α dependent signal pathway. Furthermore, the early polarization of macrophages, collagen deposition and angiogenesis in rat acute wound model, and the increased blood perfusion in mouse skin flap model have confirmed that the bio-mimicking hydrogel realized precise soft tissue remodeling and opens new avenues for the phased repair of different tissues such as nerve, myocardium, and even bone. KeAi Publishing 2021-05-11 /pmc/articles/PMC8134719/ /pubmed/34027237 http://dx.doi.org/10.1016/j.bioactmat.2021.04.039 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Cai, Zhengwei Saiding, Qimanguli Cheng, Liang Zhang, Liucheng Wang, Zhen Wang, Fei Chen, Xinliang Chen, Gang Deng, Lianfu Cui, Wenguo Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue |
title | Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue |
title_full | Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue |
title_fullStr | Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue |
title_full_unstemmed | Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue |
title_short | Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue |
title_sort | capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134719/ https://www.ncbi.nlm.nih.gov/pubmed/34027237 http://dx.doi.org/10.1016/j.bioactmat.2021.04.039 |
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