Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice

Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were foun...

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Detalles Bibliográficos
Autores principales: Jang, Young-Jin, Aravinthan, Adithan, Hossain, Mohammad Amjad, Kopalli, Spandana Rajendra, Kim, Bumseok, Kim, Nam Soo, Kang, Chang-Won, Kim, Jong-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134846/
https://www.ncbi.nlm.nih.gov/pubmed/34025138
http://dx.doi.org/10.1016/j.jgr.2020.06.001
Descripción
Sumario:Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice.

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