Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events

We identified the prevalence of elevated high-sensitivity C-reactive protein and interleukin-6 in patients with recent cardiovascular (CV) events with or without prediabetes/diabetes, and in a control group of patients with remote CV events. Interleukin-6 was elevated in patients with prediabetes/di...

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Autores principales: Boczar, Kevin E., Liu, Peter, Chong, Aun Yeong, So, Derek, Dowlatshahi, Dar, Rayner, Katey, Beanlands, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Emerging Evidence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134934/
https://www.ncbi.nlm.nih.gov/pubmed/34027372
http://dx.doi.org/10.1016/j.cjco.2020.12.020
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author Boczar, Kevin E.
Liu, Peter
Chong, Aun Yeong
So, Derek
Dowlatshahi, Dar
Rayner, Katey
Beanlands, Rob
author_facet Boczar, Kevin E.
Liu, Peter
Chong, Aun Yeong
So, Derek
Dowlatshahi, Dar
Rayner, Katey
Beanlands, Rob
author_sort Boczar, Kevin E.
collection PubMed
description We identified the prevalence of elevated high-sensitivity C-reactive protein and interleukin-6 in patients with recent cardiovascular (CV) events with or without prediabetes/diabetes, and in a control group of patients with remote CV events. Interleukin-6 was elevated in patients with prediabetes/diabetes and recent CV events (median, 4.84 pg/mL; interquartile range, 3.27-7.45) compared with patients with remote events (2.36 pg/mL; interquartile range, 1.09-4.00). There was a trend for elevated high-sensitivity C-reactive protein in patients with acute events and prediabetes/diabetes (P = 0.147). This supports the notion that patients with prediabetes/diabetes and recent CV events have higher inflammatory burdens than patients without recent CV events or dysglycemia.
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spelling pubmed-81349342021-05-21 Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events Boczar, Kevin E. Liu, Peter Chong, Aun Yeong So, Derek Dowlatshahi, Dar Rayner, Katey Beanlands, Rob CJC Open Emerging Evidence We identified the prevalence of elevated high-sensitivity C-reactive protein and interleukin-6 in patients with recent cardiovascular (CV) events with or without prediabetes/diabetes, and in a control group of patients with remote CV events. Interleukin-6 was elevated in patients with prediabetes/diabetes and recent CV events (median, 4.84 pg/mL; interquartile range, 3.27-7.45) compared with patients with remote events (2.36 pg/mL; interquartile range, 1.09-4.00). There was a trend for elevated high-sensitivity C-reactive protein in patients with acute events and prediabetes/diabetes (P = 0.147). This supports the notion that patients with prediabetes/diabetes and recent CV events have higher inflammatory burdens than patients without recent CV events or dysglycemia. Elsevier 2020-12-31 /pmc/articles/PMC8134934/ /pubmed/34027372 http://dx.doi.org/10.1016/j.cjco.2020.12.020 Text en Crown Copyright © 2020 Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Emerging Evidence
Boczar, Kevin E.
Liu, Peter
Chong, Aun Yeong
So, Derek
Dowlatshahi, Dar
Rayner, Katey
Beanlands, Rob
Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events
title Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events
title_full Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events
title_fullStr Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events
title_full_unstemmed Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events
title_short Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events
title_sort observational cross-sectional study of inflammatory markers after transient ischemic attacks, acute coronary syndromes, and vascular stroke events
topic Emerging Evidence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134934/
https://www.ncbi.nlm.nih.gov/pubmed/34027372
http://dx.doi.org/10.1016/j.cjco.2020.12.020
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