17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19% (p < 0.0001, log‐rank test) and 11% (p = 0.007) when fed at 14.4 ppm starting at 16 and 20 months, respectively. 90th percentile li...

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Detalles Bibliográficos
Autores principales: Harrison, David E., Strong, Randy, Reifsnyder, Peter, Kumar, Navasuja, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A., Lopez‐Cruzan, Marisa, Macchiarini, Francesca, Nelson, James F., Markewych, Adrian, Bitto, Alessandro, Sindler, Amy L., Cortopassi, Gino, Kavanagh, Kylie, Leng, Lin, Bucala, Richard, Rosenthal, Nadia, Salmon, Adam, Stearns, Timothy M., Bogue, Molly, Miller, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135004/
https://www.ncbi.nlm.nih.gov/pubmed/33788371
http://dx.doi.org/10.1111/acel.13328

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