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Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging

Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic underpinnings of aging effects in the female reproductive axi...

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Autores principales: Kordowitzki, Paweł, Haghani, Amin, Zoller, Joseph A., Li, Caesar Z., Raj, Ken, Spangler, Matthew L., Horvath, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135012/
https://www.ncbi.nlm.nih.gov/pubmed/33797841
http://dx.doi.org/10.1111/acel.13349
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author Kordowitzki, Paweł
Haghani, Amin
Zoller, Joseph A.
Li, Caesar Z.
Raj, Ken
Spangler, Matthew L.
Horvath, Steve
author_facet Kordowitzki, Paweł
Haghani, Amin
Zoller, Joseph A.
Li, Caesar Z.
Raj, Ken
Spangler, Matthew L.
Horvath, Steve
author_sort Kordowitzki, Paweł
collection PubMed
description Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic underpinnings of aging effects in the female reproductive axis, several DNA methylation‐based biomarkers of aging (epigenetic clocks) for bovine oocytes are presented. One such clock was germane to only oocytes, while a dual‐tissue clock was highly predictive of age in both oocytes and blood. Dual species clocks that apply to both humans and cattle were also developed and evaluated. These epigenetic clocks can be used to accurately estimate the biological age of oocytes. Both epigenetic clock studies and epigenome‐wide association studies revealed that blood and oocytes differ substantially with respect to aging and the underlying epigenetic signatures that potentially influence the aging process. The rate of epigenetic aging was found to be slower in oocytes compared to blood; however, oocytes appeared to begin at an older epigenetic age. The epigenetic clocks for oocytes are expected to address questions in the field of reproductive aging, including the central question: how to slow aging of oocytes.
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spelling pubmed-81350122021-05-21 Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging Kordowitzki, Paweł Haghani, Amin Zoller, Joseph A. Li, Caesar Z. Raj, Ken Spangler, Matthew L. Horvath, Steve Aging Cell Original Articles Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic underpinnings of aging effects in the female reproductive axis, several DNA methylation‐based biomarkers of aging (epigenetic clocks) for bovine oocytes are presented. One such clock was germane to only oocytes, while a dual‐tissue clock was highly predictive of age in both oocytes and blood. Dual species clocks that apply to both humans and cattle were also developed and evaluated. These epigenetic clocks can be used to accurately estimate the biological age of oocytes. Both epigenetic clock studies and epigenome‐wide association studies revealed that blood and oocytes differ substantially with respect to aging and the underlying epigenetic signatures that potentially influence the aging process. The rate of epigenetic aging was found to be slower in oocytes compared to blood; however, oocytes appeared to begin at an older epigenetic age. The epigenetic clocks for oocytes are expected to address questions in the field of reproductive aging, including the central question: how to slow aging of oocytes. John Wiley and Sons Inc. 2021-04-02 2021-05 /pmc/articles/PMC8135012/ /pubmed/33797841 http://dx.doi.org/10.1111/acel.13349 Text en © 2021 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Kordowitzki, Paweł
Haghani, Amin
Zoller, Joseph A.
Li, Caesar Z.
Raj, Ken
Spangler, Matthew L.
Horvath, Steve
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
title Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
title_full Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
title_fullStr Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
title_full_unstemmed Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
title_short Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
title_sort epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135012/
https://www.ncbi.nlm.nih.gov/pubmed/33797841
http://dx.doi.org/10.1111/acel.13349
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