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Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab

Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in...

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Detalles Bibliográficos
Autores principales: Diarra, Ava, Gantois, Guillaume, Lazrek, Mouna, Verdier, Basile, Elsermans, Vincent, Zephir, Hélène, Longère, Benjamin, Gkizas, Xristos, Goeminne, Céline, Lemesle, Gilles, Juthier, Francis, Bene, Johana, Launay, David, Dubois, Romain, Morell-Dubois, Sandrine, Vuotto, Fanny, Piton, Anne-Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Radcliffe Cardiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135016/
https://www.ncbi.nlm.nih.gov/pubmed/34035954
http://dx.doi.org/10.15420/cfr.2020.33
Descripción
Sumario:Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in the literature suggest a higher risk of infection following repeated rituximab therapy, including viral infection. However, observations of enterovirus-related myocarditis in the context of rituximab treatment are scarce. The authors describe the case of a patient with neuromyelitis optica spectrum disorder who developed severe and fatal enterovirus-related myocarditis after rituximab therapy with a difficult differential diagnosis of autoimmune or giant-cell myocarditis. This case highlights the importance of complete diagnostic workup in difficult cases of myocarditis, including endomyocardial biopsies.