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Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab
Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Radcliffe Cardiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135016/ https://www.ncbi.nlm.nih.gov/pubmed/34035954 http://dx.doi.org/10.15420/cfr.2020.33 |
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author | Diarra, Ava Gantois, Guillaume Lazrek, Mouna Verdier, Basile Elsermans, Vincent Zephir, Hélène Longère, Benjamin Gkizas, Xristos Goeminne, Céline Lemesle, Gilles Juthier, Francis Bene, Johana Launay, David Dubois, Romain Morell-Dubois, Sandrine Vuotto, Fanny Piton, Anne-Laure |
author_facet | Diarra, Ava Gantois, Guillaume Lazrek, Mouna Verdier, Basile Elsermans, Vincent Zephir, Hélène Longère, Benjamin Gkizas, Xristos Goeminne, Céline Lemesle, Gilles Juthier, Francis Bene, Johana Launay, David Dubois, Romain Morell-Dubois, Sandrine Vuotto, Fanny Piton, Anne-Laure |
author_sort | Diarra, Ava |
collection | PubMed |
description | Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in the literature suggest a higher risk of infection following repeated rituximab therapy, including viral infection. However, observations of enterovirus-related myocarditis in the context of rituximab treatment are scarce. The authors describe the case of a patient with neuromyelitis optica spectrum disorder who developed severe and fatal enterovirus-related myocarditis after rituximab therapy with a difficult differential diagnosis of autoimmune or giant-cell myocarditis. This case highlights the importance of complete diagnostic workup in difficult cases of myocarditis, including endomyocardial biopsies. |
format | Online Article Text |
id | pubmed-8135016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Radcliffe Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-81350162021-05-24 Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab Diarra, Ava Gantois, Guillaume Lazrek, Mouna Verdier, Basile Elsermans, Vincent Zephir, Hélène Longère, Benjamin Gkizas, Xristos Goeminne, Céline Lemesle, Gilles Juthier, Francis Bene, Johana Launay, David Dubois, Romain Morell-Dubois, Sandrine Vuotto, Fanny Piton, Anne-Laure Card Fail Rev Clinical Syndromes Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in the literature suggest a higher risk of infection following repeated rituximab therapy, including viral infection. However, observations of enterovirus-related myocarditis in the context of rituximab treatment are scarce. The authors describe the case of a patient with neuromyelitis optica spectrum disorder who developed severe and fatal enterovirus-related myocarditis after rituximab therapy with a difficult differential diagnosis of autoimmune or giant-cell myocarditis. This case highlights the importance of complete diagnostic workup in difficult cases of myocarditis, including endomyocardial biopsies. Radcliffe Cardiology 2021-05-12 /pmc/articles/PMC8135016/ /pubmed/34035954 http://dx.doi.org/10.15420/cfr.2020.33 Text en Copyright © 2021, Radcliffe Cardiology https://creativecommons.org/licenses/by-nc/4.0/This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly. |
spellingShingle | Clinical Syndromes Diarra, Ava Gantois, Guillaume Lazrek, Mouna Verdier, Basile Elsermans, Vincent Zephir, Hélène Longère, Benjamin Gkizas, Xristos Goeminne, Céline Lemesle, Gilles Juthier, Francis Bene, Johana Launay, David Dubois, Romain Morell-Dubois, Sandrine Vuotto, Fanny Piton, Anne-Laure Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab |
title | Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab |
title_full | Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab |
title_fullStr | Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab |
title_full_unstemmed | Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab |
title_short | Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab |
title_sort | fatal enterovirus-related myocarditis in a patient with devic’s syndrome treated with rituximab |
topic | Clinical Syndromes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135016/ https://www.ncbi.nlm.nih.gov/pubmed/34035954 http://dx.doi.org/10.15420/cfr.2020.33 |
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