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Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab

Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in...

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Autores principales: Diarra, Ava, Gantois, Guillaume, Lazrek, Mouna, Verdier, Basile, Elsermans, Vincent, Zephir, Hélène, Longère, Benjamin, Gkizas, Xristos, Goeminne, Céline, Lemesle, Gilles, Juthier, Francis, Bene, Johana, Launay, David, Dubois, Romain, Morell-Dubois, Sandrine, Vuotto, Fanny, Piton, Anne-Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Radcliffe Cardiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135016/
https://www.ncbi.nlm.nih.gov/pubmed/34035954
http://dx.doi.org/10.15420/cfr.2020.33
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author Diarra, Ava
Gantois, Guillaume
Lazrek, Mouna
Verdier, Basile
Elsermans, Vincent
Zephir, Hélène
Longère, Benjamin
Gkizas, Xristos
Goeminne, Céline
Lemesle, Gilles
Juthier, Francis
Bene, Johana
Launay, David
Dubois, Romain
Morell-Dubois, Sandrine
Vuotto, Fanny
Piton, Anne-Laure
author_facet Diarra, Ava
Gantois, Guillaume
Lazrek, Mouna
Verdier, Basile
Elsermans, Vincent
Zephir, Hélène
Longère, Benjamin
Gkizas, Xristos
Goeminne, Céline
Lemesle, Gilles
Juthier, Francis
Bene, Johana
Launay, David
Dubois, Romain
Morell-Dubois, Sandrine
Vuotto, Fanny
Piton, Anne-Laure
author_sort Diarra, Ava
collection PubMed
description Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in the literature suggest a higher risk of infection following repeated rituximab therapy, including viral infection. However, observations of enterovirus-related myocarditis in the context of rituximab treatment are scarce. The authors describe the case of a patient with neuromyelitis optica spectrum disorder who developed severe and fatal enterovirus-related myocarditis after rituximab therapy with a difficult differential diagnosis of autoimmune or giant-cell myocarditis. This case highlights the importance of complete diagnostic workup in difficult cases of myocarditis, including endomyocardial biopsies.
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spelling pubmed-81350162021-05-24 Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab Diarra, Ava Gantois, Guillaume Lazrek, Mouna Verdier, Basile Elsermans, Vincent Zephir, Hélène Longère, Benjamin Gkizas, Xristos Goeminne, Céline Lemesle, Gilles Juthier, Francis Bene, Johana Launay, David Dubois, Romain Morell-Dubois, Sandrine Vuotto, Fanny Piton, Anne-Laure Card Fail Rev Clinical Syndromes Enteroviruses are a frequent source of infection and among the most common central nervous system viral pathogens. Enteroviruses – in particular, the Coxsackie B viruses – are a known cause of myocarditis. Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody. Many reports in the literature suggest a higher risk of infection following repeated rituximab therapy, including viral infection. However, observations of enterovirus-related myocarditis in the context of rituximab treatment are scarce. The authors describe the case of a patient with neuromyelitis optica spectrum disorder who developed severe and fatal enterovirus-related myocarditis after rituximab therapy with a difficult differential diagnosis of autoimmune or giant-cell myocarditis. This case highlights the importance of complete diagnostic workup in difficult cases of myocarditis, including endomyocardial biopsies. Radcliffe Cardiology 2021-05-12 /pmc/articles/PMC8135016/ /pubmed/34035954 http://dx.doi.org/10.15420/cfr.2020.33 Text en Copyright © 2021, Radcliffe Cardiology https://creativecommons.org/licenses/by-nc/4.0/This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.
spellingShingle Clinical Syndromes
Diarra, Ava
Gantois, Guillaume
Lazrek, Mouna
Verdier, Basile
Elsermans, Vincent
Zephir, Hélène
Longère, Benjamin
Gkizas, Xristos
Goeminne, Céline
Lemesle, Gilles
Juthier, Francis
Bene, Johana
Launay, David
Dubois, Romain
Morell-Dubois, Sandrine
Vuotto, Fanny
Piton, Anne-Laure
Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab
title Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab
title_full Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab
title_fullStr Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab
title_full_unstemmed Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab
title_short Fatal Enterovirus-related Myocarditis in a Patient with Devic’s Syndrome Treated with Rituximab
title_sort fatal enterovirus-related myocarditis in a patient with devic’s syndrome treated with rituximab
topic Clinical Syndromes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135016/
https://www.ncbi.nlm.nih.gov/pubmed/34035954
http://dx.doi.org/10.15420/cfr.2020.33
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