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A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells

The translocation of sphingosine kinase 1 (SK1) to the plasma membrane (PM) is crucial in promoting oncogenesis. We have previously proposed that SK1 exists as both a monomer and dimer in equilibrium, although it is unclear whether these species translocate to the PM via the same or different mechan...

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Detalles Bibliográficos
Autores principales: Brown, Ryan D.R., Veerman, Ben E.P., Oh, Jeongah, Tate, Rothwelle J., Torta, Federico, Cunningham, Margaret R., Adams, David R., Pyne, Susan, Pyne, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135045/
https://www.ncbi.nlm.nih.gov/pubmed/33865856
http://dx.doi.org/10.1016/j.jbc.2021.100674