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Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol

We hypothesized that rapamycin (Rapa), acarbose (ACA), which both increase mouse lifespan, and 17α‐estradiol, which increases lifespan in males (17aE2) all share common intracellular signaling pathways with long‐lived Snell dwarf, PAPPA‐KO, and Ghr−/− mice. The long‐lived mutant mice exhibit reducti...

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Detalles Bibliográficos
Autores principales: Shen, Ziqian, Hinson, Abby, Miller, Richard A., Garcia, Gonzalo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135077/
https://www.ncbi.nlm.nih.gov/pubmed/33742521
http://dx.doi.org/10.1111/acel.13345

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