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Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer’s disease

Mitochondrial dysfunction is one of the early pathological features of Alzheimer's disease (AD). Accumulation of cerebral and mitochondrial Aβ links to mitochondrial and synaptic toxicity. We have previously demonstrated the mechanism by which presequence peptidase (PITRM1)‐mediated clearance o...

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Detalles Bibliográficos
Autores principales:	Du, Fang, Yu, Qing, Yan, Shijun, Zhang, Zhihua, Vangavaragu, Jhansi Rani, Chen, Doris, Yan, Shi Fang, Yan, Shirley ShiDu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135081/ https://www.ncbi.nlm.nih.gov/pubmed/33951271 http://dx.doi.org/10.1111/acel.13368

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