Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR

Mitochondrial prohibitins (PHB) are highly conserved proteins with a peculiar effect on lifespan. While PHB depletion shortens lifespan of wild‐type animals, it enhances longevity of a plethora of metabolically compromised mutants, including target of rapamycin complex 2 (TORC2) mutants sgk‐1 and ri...

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Detalles Bibliográficos
Autores principales: de la Cruz‐Ruiz, Patricia, Hernando‐Rodríguez, Blanca, Pérez‐Jiménez, Mercedes M., Rodríguez‐Palero, María Jesús, Martínez‐Bueno, Manuel D., Pla, Antoni, Gatsi, Roxani, Artal‐Sanz, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135086/
https://www.ncbi.nlm.nih.gov/pubmed/33939875
http://dx.doi.org/10.1111/acel.13359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135086/
https://www.ncbi.nlm.nih.gov/pubmed/33939875
http://dx.doi.org/10.1111/acel.13359

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