Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation

BACKGROUND: Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fibroblasts. METHODS: The role of HDAC7 in CTGF production caused by ET-1 stimula...

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Detalles Bibliográficos
Autores principales: Hua, Hung-Sheng, Wen, Heng-Ching, Weng, Chih-Ming, Lee, Hong-Sheng, Chen, Bing-Chang, Lin, Chien-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135160/
https://www.ncbi.nlm.nih.gov/pubmed/34011384
http://dx.doi.org/10.1186/s12929-021-00735-5

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