Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan patch o...

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Detalles Bibliográficos
Autores principales: Williams, Wilton B., Meyerhoff, R. Ryan, Edwards, R.J., Li, Hui, Manne, Kartik, Nicely, Nathan I., Henderson, Rory, Zhou, Ye, Janowska, Katarzyna, Mansouri, Katayoun, Gobeil, Sophie, Evangelous, Tyler, Hora, Bhavna, Berry, Madison, Abuahmad, A. Yousef, Sprenz, Jordan, Deyton, Margaret, Stalls, Victoria, Kopp, Megan, Hsu, Allen L., Borgnia, Mario J., Stewart-Jones, Guillaume B.E., Lee, Matthew S., Bronkema, Naomi, Moody, M. Anthony, Wiehe, Kevin, Bradley, Todd, Alam, S. Munir, Parks, Robert J., Foulger, Andrew, Oguin, Thomas, Sempowski, Gregory D., Bonsignori, Mattia, LaBranche, Celia C., Montefiori, David C., Seaman, Michael, Santra, Sampa, Perfect, John, Francica, Joseph R., Lynn, Geoffrey M., Aussedat, Baptiste, Walkowicz, William E., Laga, Richard, Kelsoe, Garnett, Saunders, Kevin O., Fera, Daniela, Kwong, Peter D., Seder, Robert A., Bartesaghi, Alberto, Shaw, George M., Acharya, Priyamvada, Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135257/
https://www.ncbi.nlm.nih.gov/pubmed/34019795
http://dx.doi.org/10.1016/j.cell.2021.04.042

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