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Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study

BACKGROUND: Influenza epidemics were initially considered to be a suitable model for the COVID-19 epidemic, but there is a lack of data concerning patients with chronic respiratory diseases (CRDs), who were supposed to be at risk of severe forms of COVID-19. METHODS: This nationwide retrospective co...

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Autores principales: Beltramo, Guillaume, Cottenet, Jonathan, Mariet, Anne-Sophie, Georges, Marjolaine, Piroth, Lionel, Tubert-Bitter, Pascale, Bonniaud, Philippe, Quantin, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135927/
https://www.ncbi.nlm.nih.gov/pubmed/34016619
http://dx.doi.org/10.1183/13993003.04474-2020
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author Beltramo, Guillaume
Cottenet, Jonathan
Mariet, Anne-Sophie
Georges, Marjolaine
Piroth, Lionel
Tubert-Bitter, Pascale
Bonniaud, Philippe
Quantin, Catherine
author_facet Beltramo, Guillaume
Cottenet, Jonathan
Mariet, Anne-Sophie
Georges, Marjolaine
Piroth, Lionel
Tubert-Bitter, Pascale
Bonniaud, Philippe
Quantin, Catherine
author_sort Beltramo, Guillaume
collection PubMed
description BACKGROUND: Influenza epidemics were initially considered to be a suitable model for the COVID-19 epidemic, but there is a lack of data concerning patients with chronic respiratory diseases (CRDs), who were supposed to be at risk of severe forms of COVID-19. METHODS: This nationwide retrospective cohort study describes patients with prior lung disease hospitalised for COVID-19 (March–April 2020) or influenza (2018–2019 influenza outbreak). We compared the resulting pulmonary complications, need for intensive care and in-hospital mortality depending on respiratory history and virus. RESULTS: In the 89 530 COVID-19 cases, 16.03% had at least one CRD, which was significantly less frequently than in the 45 819 seasonal influenza patients. Patients suffering from chronic respiratory failure, chronic obstructive pulmonary disease, asthma, cystic fibrosis and pulmonary hypertension were under-represented, contrary to those with lung cancer, sleep apnoea, emphysema and interstitial lung diseases. COVID-19 patients with CRDs developed significantly more ventilator-associated pneumonia and pulmonary embolism than influenza patients. They needed intensive care significantly more often and had a higher mortality rate (except for asthma) when compared with patients with COVID-19 but without CRDs or patients with influenza. CONCLUSIONS: Patients with prior respiratory diseases were globally less likely to be hospitalised for COVID-19 than for influenza, but were at higher risk of developing severe COVID-19 and had a higher mortality rate compared with influenza patients and patients without a history of respiratory illness.
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spelling pubmed-81359272021-05-21 Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study Beltramo, Guillaume Cottenet, Jonathan Mariet, Anne-Sophie Georges, Marjolaine Piroth, Lionel Tubert-Bitter, Pascale Bonniaud, Philippe Quantin, Catherine Eur Respir J Original Research Articles BACKGROUND: Influenza epidemics were initially considered to be a suitable model for the COVID-19 epidemic, but there is a lack of data concerning patients with chronic respiratory diseases (CRDs), who were supposed to be at risk of severe forms of COVID-19. METHODS: This nationwide retrospective cohort study describes patients with prior lung disease hospitalised for COVID-19 (March–April 2020) or influenza (2018–2019 influenza outbreak). We compared the resulting pulmonary complications, need for intensive care and in-hospital mortality depending on respiratory history and virus. RESULTS: In the 89 530 COVID-19 cases, 16.03% had at least one CRD, which was significantly less frequently than in the 45 819 seasonal influenza patients. Patients suffering from chronic respiratory failure, chronic obstructive pulmonary disease, asthma, cystic fibrosis and pulmonary hypertension were under-represented, contrary to those with lung cancer, sleep apnoea, emphysema and interstitial lung diseases. COVID-19 patients with CRDs developed significantly more ventilator-associated pneumonia and pulmonary embolism than influenza patients. They needed intensive care significantly more often and had a higher mortality rate (except for asthma) when compared with patients with COVID-19 but without CRDs or patients with influenza. CONCLUSIONS: Patients with prior respiratory diseases were globally less likely to be hospitalised for COVID-19 than for influenza, but were at higher risk of developing severe COVID-19 and had a higher mortality rate compared with influenza patients and patients without a history of respiratory illness. European Respiratory Society 2021-12-09 /pmc/articles/PMC8135927/ /pubmed/34016619 http://dx.doi.org/10.1183/13993003.04474-2020 Text en Copyright ©The authors 2021. https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Articles
Beltramo, Guillaume
Cottenet, Jonathan
Mariet, Anne-Sophie
Georges, Marjolaine
Piroth, Lionel
Tubert-Bitter, Pascale
Bonniaud, Philippe
Quantin, Catherine
Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study
title Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study
title_full Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study
title_fullStr Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study
title_full_unstemmed Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study
title_short Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study
title_sort chronic respiratory diseases are predictors of severe outcome in covid-19 hospitalised patients: a nationwide study
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135927/
https://www.ncbi.nlm.nih.gov/pubmed/34016619
http://dx.doi.org/10.1183/13993003.04474-2020
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