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Defining the lineage of thermogenic perivascular adipose tissue

Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated with large blood vessels, corresponding to perivascular...

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Autores principales: Angueira, Anthony R., Sakers, Alexander P., Holman, Corey D., Cheng, Lan, Arbocco, Michelangella N., Shamsi, Farnaz, Lynes, Matthew D., Shrestha, Rojesh, Okada, Chihiro, Batmanov, Kirill, Susztak, Katalin, Tseng, Yu-Hua, Liaw, Lucy, Seale, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136151/
https://www.ncbi.nlm.nih.gov/pubmed/33846639
http://dx.doi.org/10.1038/s42255-021-00380-0
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author Angueira, Anthony R.
Sakers, Alexander P.
Holman, Corey D.
Cheng, Lan
Arbocco, Michelangella N.
Shamsi, Farnaz
Lynes, Matthew D.
Shrestha, Rojesh
Okada, Chihiro
Batmanov, Kirill
Susztak, Katalin
Tseng, Yu-Hua
Liaw, Lucy
Seale, Patrick
author_facet Angueira, Anthony R.
Sakers, Alexander P.
Holman, Corey D.
Cheng, Lan
Arbocco, Michelangella N.
Shamsi, Farnaz
Lynes, Matthew D.
Shrestha, Rojesh
Okada, Chihiro
Batmanov, Kirill
Susztak, Katalin
Tseng, Yu-Hua
Liaw, Lucy
Seale, Patrick
author_sort Angueira, Anthony R.
collection PubMed
description Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated with large blood vessels, corresponding to perivascular adipose tissue (PVAT). However, the cellular origins of PVAT are poorly understood. Here, we determine the identity of perivascular adipocyte progenitors in mice and humans. In mice, thoracic PVAT develops from a fibroblastic lineage, consisting of progenitor cells (Pdgfra+; Ly6a+; Pparg-) and preadipocytes (Pdgfra+; Ly6a+; Pparg+), which share transcriptional similarity with analogous cell types in white adipose tissue. Interestingly, the aortic adventitia of adult animals contains a population of adipogenic smooth muscle cells (SMCs) (Myh11+; Pdgfra-; Pparg+) that contribute to perivascular adipocyte formation. Similarly, human PVAT contains presumptive fibroblastic and SMC-like adipocyte progenitors, as revealed by single nucleus RNAseq. Taken together, these studies define distinct populations of progenitor cells for thermogenic PVAT, providing a foundation for developing strategies to augment brown fat activity.
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spelling pubmed-81361512021-10-12 Defining the lineage of thermogenic perivascular adipose tissue Angueira, Anthony R. Sakers, Alexander P. Holman, Corey D. Cheng, Lan Arbocco, Michelangella N. Shamsi, Farnaz Lynes, Matthew D. Shrestha, Rojesh Okada, Chihiro Batmanov, Kirill Susztak, Katalin Tseng, Yu-Hua Liaw, Lucy Seale, Patrick Nat Metab Article Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated with large blood vessels, corresponding to perivascular adipose tissue (PVAT). However, the cellular origins of PVAT are poorly understood. Here, we determine the identity of perivascular adipocyte progenitors in mice and humans. In mice, thoracic PVAT develops from a fibroblastic lineage, consisting of progenitor cells (Pdgfra+; Ly6a+; Pparg-) and preadipocytes (Pdgfra+; Ly6a+; Pparg+), which share transcriptional similarity with analogous cell types in white adipose tissue. Interestingly, the aortic adventitia of adult animals contains a population of adipogenic smooth muscle cells (SMCs) (Myh11+; Pdgfra-; Pparg+) that contribute to perivascular adipocyte formation. Similarly, human PVAT contains presumptive fibroblastic and SMC-like adipocyte progenitors, as revealed by single nucleus RNAseq. Taken together, these studies define distinct populations of progenitor cells for thermogenic PVAT, providing a foundation for developing strategies to augment brown fat activity. 2021-04-12 2021-04 /pmc/articles/PMC8136151/ /pubmed/33846639 http://dx.doi.org/10.1038/s42255-021-00380-0 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Angueira, Anthony R.
Sakers, Alexander P.
Holman, Corey D.
Cheng, Lan
Arbocco, Michelangella N.
Shamsi, Farnaz
Lynes, Matthew D.
Shrestha, Rojesh
Okada, Chihiro
Batmanov, Kirill
Susztak, Katalin
Tseng, Yu-Hua
Liaw, Lucy
Seale, Patrick
Defining the lineage of thermogenic perivascular adipose tissue
title Defining the lineage of thermogenic perivascular adipose tissue
title_full Defining the lineage of thermogenic perivascular adipose tissue
title_fullStr Defining the lineage of thermogenic perivascular adipose tissue
title_full_unstemmed Defining the lineage of thermogenic perivascular adipose tissue
title_short Defining the lineage of thermogenic perivascular adipose tissue
title_sort defining the lineage of thermogenic perivascular adipose tissue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136151/
https://www.ncbi.nlm.nih.gov/pubmed/33846639
http://dx.doi.org/10.1038/s42255-021-00380-0
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