Cytogenetic and mutational analysis and outcome assessment of a cohort of 284 children with de novo acute myeloid leukemia reveal complex karyotype as an adverse risk factor for inferior survival

BACKGROUND: Acute myeloid leukemia (AML) is rare in children. Although complex karyotype (CK) defined as ≥ 3 cytogenetic abnormalities is an adverse risk factor in adult AML, its prognostic impact on childhood AML remains to be determined. RESULTS: We studied the prevalence, cytogenetic and mutation...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Wang, Xingjuan, Dou, Hu, Yang, Zhenzhen, Bi, Junqin, Huang, Yi, Lu, Ling, Yu, Jie, Bao, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136172/
https://www.ncbi.nlm.nih.gov/pubmed/34011412
http://dx.doi.org/10.1186/s13039-021-00547-0

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