Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1

Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by a non-coding CTG repeat expansion in the DMPK gene. This mutation generates a toxic CUG RNA that interferes with the RNA processing of target genes in multiple tissues. Despite debilitating neurological impairment, the pathophysio...

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Detalles Bibliográficos
Autores principales: González-Barriga, Anchel, Lallemant, Louison, Dincã, Diana M., Braz, Sandra O., Polvèche, Hélène, Magneron, Paul, Pionneau, Cédric, Huguet-Lachon, Aline, Claude, Jean-Baptiste, Chhuon, Cerina, Guerrera, Ida Chiara, Bourgeois, Cyril F., Auboeuf, Didier, Gourdon, Geneviève, Gomes-Pereira, Mário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136287/
https://www.ncbi.nlm.nih.gov/pubmed/34025359
http://dx.doi.org/10.3389/fncel.2021.662035

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