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Biogenesis of RNA Polymerases in Yeast

Eukaryotic RNA polymerases (RNA pols) transcriptional processes have been extensively investigated, and the structural analysis of eukaryotic RNA pols has been explored. However, the global assembly and biogenesis of these heteromultimeric complexes have been narrowly studied. Despite nuclear transc...

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Autores principales: Garrido-Godino, Ana I., Gutiérrez-Santiago, Francisco, Navarro, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136413/
https://www.ncbi.nlm.nih.gov/pubmed/34026841
http://dx.doi.org/10.3389/fmolb.2021.669300
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author Garrido-Godino, Ana I.
Gutiérrez-Santiago, Francisco
Navarro, Francisco
author_facet Garrido-Godino, Ana I.
Gutiérrez-Santiago, Francisco
Navarro, Francisco
author_sort Garrido-Godino, Ana I.
collection PubMed
description Eukaryotic RNA polymerases (RNA pols) transcriptional processes have been extensively investigated, and the structural analysis of eukaryotic RNA pols has been explored. However, the global assembly and biogenesis of these heteromultimeric complexes have been narrowly studied. Despite nuclear transcription being carried out by three RNA polymerases in eukaryotes (five in plants) with specificity in the synthesis of different RNA types, the biogenesis process has been proposed to be similar, at least for RNA pol II, to that of bacteria, which contains only one RNA pol. The formation of three different interacting subassembly complexes to conform the complete enzyme in the cytoplasm, prior to its nuclear import, has been assumed. In Saccharomyces cerevisiae, recent studies have examined in depth the biogenesis of RNA polymerases by characterizing some elements involved in the assembly of these multisubunit complexes, some of which are conserved in humans. This study reviews the latest studies governing the mechanisms and proteins described as being involved in the biogenesis of RNA polymerases in yeast.
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spelling pubmed-81364132021-05-21 Biogenesis of RNA Polymerases in Yeast Garrido-Godino, Ana I. Gutiérrez-Santiago, Francisco Navarro, Francisco Front Mol Biosci Molecular Biosciences Eukaryotic RNA polymerases (RNA pols) transcriptional processes have been extensively investigated, and the structural analysis of eukaryotic RNA pols has been explored. However, the global assembly and biogenesis of these heteromultimeric complexes have been narrowly studied. Despite nuclear transcription being carried out by three RNA polymerases in eukaryotes (five in plants) with specificity in the synthesis of different RNA types, the biogenesis process has been proposed to be similar, at least for RNA pol II, to that of bacteria, which contains only one RNA pol. The formation of three different interacting subassembly complexes to conform the complete enzyme in the cytoplasm, prior to its nuclear import, has been assumed. In Saccharomyces cerevisiae, recent studies have examined in depth the biogenesis of RNA polymerases by characterizing some elements involved in the assembly of these multisubunit complexes, some of which are conserved in humans. This study reviews the latest studies governing the mechanisms and proteins described as being involved in the biogenesis of RNA polymerases in yeast. Frontiers Media S.A. 2021-04-28 /pmc/articles/PMC8136413/ /pubmed/34026841 http://dx.doi.org/10.3389/fmolb.2021.669300 Text en Copyright © 2021 Garrido-Godino, Gutiérrez-Santiago and Navarro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Garrido-Godino, Ana I.
Gutiérrez-Santiago, Francisco
Navarro, Francisco
Biogenesis of RNA Polymerases in Yeast
title Biogenesis of RNA Polymerases in Yeast
title_full Biogenesis of RNA Polymerases in Yeast
title_fullStr Biogenesis of RNA Polymerases in Yeast
title_full_unstemmed Biogenesis of RNA Polymerases in Yeast
title_short Biogenesis of RNA Polymerases in Yeast
title_sort biogenesis of rna polymerases in yeast
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136413/
https://www.ncbi.nlm.nih.gov/pubmed/34026841
http://dx.doi.org/10.3389/fmolb.2021.669300
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