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Atrophic Dermatofibroma: A Unique Dermatofibroma Variant
Dermatofibromas are benign skin tumors with several variants, including the rare, uncommonly described atrophic dermatofibroma. To the best of our knowledge, there are currently 105 reported cases of atrophic dermatofibromas in the literature. This variant typically presents as a flat or depressed m...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136451/ https://www.ncbi.nlm.nih.gov/pubmed/34035995 http://dx.doi.org/10.7759/cureus.14570 |
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author | Gutierrez, Nikolas Calame, Antoanella Erickson, Christof Cohen, Philip R |
author_facet | Gutierrez, Nikolas Calame, Antoanella Erickson, Christof Cohen, Philip R |
author_sort | Gutierrez, Nikolas |
collection | PubMed |
description | Dermatofibromas are benign skin tumors with several variants, including the rare, uncommonly described atrophic dermatofibroma. To the best of our knowledge, there are currently 105 reported cases of atrophic dermatofibromas in the literature. This variant typically presents as a flat or depressed macule whose color can range from brown to white to red; in contrast to classic dermatofibromas that typically occur on the legs, atrophic dermatofibromas have a tendency to occur on the upper back and arms. An atrophic dermatofibroma can be clinically diagnosed; however, given the broad spectrum of clinical features of this lesion, a biopsy may be required. Characteristic pathologic features include epidermal acanthosis, basilar hyperpigmentation, fibroblast hyperplasia, and decreased or absent elastic fibers within the lesion. The pathogenesis of this lesion is not yet fully understood; however, it has been postulated that the loss of elastic fibers plays a key role in its development and characteristic atrophic appearance. We present the cases of two men with biopsy-confirmed atrophic dermatofibromas: a 47-year-old man with a pigmented macule on the right upper back and a 68-year-old man with an erythematous patch on the left posterolateral shoulder. The clinical and pathologic features of atrophic dermatofibromas are also summarized. |
format | Online Article Text |
id | pubmed-8136451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-81364512021-05-24 Atrophic Dermatofibroma: A Unique Dermatofibroma Variant Gutierrez, Nikolas Calame, Antoanella Erickson, Christof Cohen, Philip R Cureus Dermatology Dermatofibromas are benign skin tumors with several variants, including the rare, uncommonly described atrophic dermatofibroma. To the best of our knowledge, there are currently 105 reported cases of atrophic dermatofibromas in the literature. This variant typically presents as a flat or depressed macule whose color can range from brown to white to red; in contrast to classic dermatofibromas that typically occur on the legs, atrophic dermatofibromas have a tendency to occur on the upper back and arms. An atrophic dermatofibroma can be clinically diagnosed; however, given the broad spectrum of clinical features of this lesion, a biopsy may be required. Characteristic pathologic features include epidermal acanthosis, basilar hyperpigmentation, fibroblast hyperplasia, and decreased or absent elastic fibers within the lesion. The pathogenesis of this lesion is not yet fully understood; however, it has been postulated that the loss of elastic fibers plays a key role in its development and characteristic atrophic appearance. We present the cases of two men with biopsy-confirmed atrophic dermatofibromas: a 47-year-old man with a pigmented macule on the right upper back and a 68-year-old man with an erythematous patch on the left posterolateral shoulder. The clinical and pathologic features of atrophic dermatofibromas are also summarized. Cureus 2021-04-19 /pmc/articles/PMC8136451/ /pubmed/34035995 http://dx.doi.org/10.7759/cureus.14570 Text en Copyright © 2021, Gutierrez et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Dermatology Gutierrez, Nikolas Calame, Antoanella Erickson, Christof Cohen, Philip R Atrophic Dermatofibroma: A Unique Dermatofibroma Variant |
title | Atrophic Dermatofibroma: A Unique Dermatofibroma Variant |
title_full | Atrophic Dermatofibroma: A Unique Dermatofibroma Variant |
title_fullStr | Atrophic Dermatofibroma: A Unique Dermatofibroma Variant |
title_full_unstemmed | Atrophic Dermatofibroma: A Unique Dermatofibroma Variant |
title_short | Atrophic Dermatofibroma: A Unique Dermatofibroma Variant |
title_sort | atrophic dermatofibroma: a unique dermatofibroma variant |
topic | Dermatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136451/ https://www.ncbi.nlm.nih.gov/pubmed/34035995 http://dx.doi.org/10.7759/cureus.14570 |
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