Intranasal delivery of mitochondria for treatment of Parkinson’s Disease model rats lesioned with 6-hydroxydopamine

The feasibility of delivering mitochondria intranasally so as to bypass the blood–brain barrier in treating Parkinson's disease (PD), was evaluated in unilaterally 6-OHDA-lesioned rats. Intranasal infusion of allogeneic mitochondria conjugated with Pep-1 (P-Mito) or unconjugated (Mito) was perf...

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Detalles Bibliográficos
Autores principales: Chang, Jui-Chih, Chao, Yi-Chun, Chang, Huei-Shin, Wu, Yu-Ling, Chang, Hui-Ju, Lin, Yong-Shiou, Cheng, Wen-Ling, Lin, Ta-Tsung, Liu, Chin-San
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136477/
https://www.ncbi.nlm.nih.gov/pubmed/34011937
http://dx.doi.org/10.1038/s41598-021-90094-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136477/
https://www.ncbi.nlm.nih.gov/pubmed/34011937
http://dx.doi.org/10.1038/s41598-021-90094-w

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