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Were Ancestral Proteins Less Specific?

Some have hypothesized that ancestral proteins were, on average, less specific than their descendants. If true, this would provide a universal axis along which to organize protein evolution and suggests that reconstructed ancestral proteins may be uniquely powerful tools for protein engineering. Anc...

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Detalles Bibliográficos
Autores principales: Wheeler, Lucas C, Harms, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136485/
https://www.ncbi.nlm.nih.gov/pubmed/33528559
http://dx.doi.org/10.1093/molbev/msab019